The functional analysis of the mensetruation-related genes and its role in the onset and the progression of the endometriosis.
| Project/Area Number |
20791168
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Keio University |
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Principal Investigator |
ODA Hideyuki Keio University, 医学部, 研究員 (50445235)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 月経関連遺伝子 / 子宮内膜症 / sarcoglycan-delta / 磁力 / 子宮内膜症モデルマウス / microarray / 応用動物 / 幹細胞 / in vitro月経モデル / delta sarcoglycan |
|---|
| Research Abstract |
We have already had the candidate genes of the mensetruation-related genes which expression alters accoding to the menstrual period. And we found that the expression of the sarcoglycan-delta increased not only by the microarray but also by RT-PCR and immunohistochemistry. And to analyze its effect in the endometriosis we try to develop the novel endeomtriosis model mouse using the magnetic power and improve the magnet and magnetic materials.
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Report
(4 results)
Research Products
(43 results)
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[Journal Article] Stem cell-like properties of the endometrial Side population : implication in endometrial regeneration.2010
Author(s)
Masuda H, Matsuzaki Y, Hiratsu E, Ono M, Nagashima T, Kajitani T, Arase T, Oda H, Uchida H, Asada H, lto M, Yoshimura Y, Maruyama T, Okano H
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Related Report
Peer Reviewed
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[Journal Article] The UDP-glucose recepter P2RY14 triggers innate mucosal immunity in the female reproductive tract by inducing IL-8.2009
Author(s)
Arase T, Uchida H, Kajitani T, Ono M, TamakiK, Oda H, Nishikawa S, Kagami M, Nagashima T, Masuda H, Asada H, Yoshimura Y, Maruyama T
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Journal Title
J Immunol. 182
Pages: 7074-7084
Related Report
Peer Reviewed
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[Journal Article] Activation of SRC kinase and phosphorylation of signal transducer and activator of transcription-5 are required for decidual transformation of human endometrial stromal cells2008
Author(s)
Nagashima T, Maruyama T, Uchida H, Kajitani T, Arase T, Ono M, Oda H, Kagami M, Masuda H, Nishikawa S, Asada H, Yoshimura Y
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Journal Title
Endocrinology 149
Pages: 1227-1234
Related Report
Peer Reviewed
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[Journal Article] 妊娠子宮における子宮筋Side Population細胞の役割2008
Author(s)
小野政徳, 丸山哲夫, 梶谷宇, 内田浩, 荒瀬透, 各務真紀, 小田英之, 西川明花, 升田博隆, 長島隆, 太田邦明, 伊藤守, 浅田弘法, 岡野栄之, 松崎有未, 吉村泰典
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Journal Title
日本生殖内分泌学会雑誌 13
Pages: 25-29
NAID
Related Report
Peer Reviewed
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[Presentation] The role of uterine smooth muscle stem cells, isolated based on cell surface markers, in myometrial remodeling in the pregnant uterus2009
Author(s)
Ono M, Maruyama T, Kajitani T, Uchida H, Oda H, Nishikawa S, Kagami M, Arase T, Nagashima T, Masuda H, Morikawa S, Mabuchi Y, Okano Y, Matsuzaki Y, Yoshimura Y
Organizer
56th Society for Gynecologic Investigation
Place of Presentation
Glasgow, Scotland
Related Report
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[Presentation] 表面抗原を用いたヒト子宮平滑筋幹細胞の新しい分離法の開発とその妊娠至急リモデリングにおける役割2009
Author(s)
小野政徳, 丸山哲夫, 梶谷宇, 内田浩, 荒瀬透, 小田英之, 西川明花, 各務真紀, 浅田弘法, 升田博隆, 岡野栄之, 松崎有未, 吉村泰典
Organizer
第8回日本再生医療学会
Place of Presentation
東京都千代田区
Related Report
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[Presentation] 子宮平滑筋幹細胞の新しい分離法とその機能解析2008
Author(s)
小野政徳, 丸山哲夫, 梶谷宇, 内田浩, 荒瀬透, 小田英之, 西川明花, 長島隆, 升田博隆, 馬渕洋, 森川暁, 岡野栄之, 松崎有未, 吉村泰典
Organizer
第81回日本内分泌学会学術総会
Place of Presentation
青森県弘前市
Related Report
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