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The functional analysis of the mensetruation-related genes and its role in the onset and the progression of the endometriosis.

Research Project

Project/Area Number 20791168
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Obstetrics and gynecology
Research InstitutionKeio University

Principal Investigator

ODA Hideyuki  Keio University, 医学部, 研究員 (50445235)

Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords月経関連遺伝子 / 子宮内膜症 / sarcoglycan-delta / 磁力 / 子宮内膜症モデルマウス / microarray / 応用動物 / 幹細胞 / in vitro月経モデル / delta sarcoglycan
Research Abstract

We have already had the candidate genes of the mensetruation-related genes which expression alters accoding to the menstrual period. And we found that the expression of the sarcoglycan-delta increased not only by the microarray but also by RT-PCR and immunohistochemistry. And to analyze its effect in the endometriosis we try to develop the novel endeomtriosis model mouse using the magnetic power and improve the magnet and magnetic materials.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (43 results)

All 2010 2009 2008

All Journal Article (23 results) (of which Peer Reviewed: 23 results) Presentation (20 results)

  • [Journal Article] Stem Cell-Like Properties of the Endometrial Side Population : Implication in Endometrial Regeneration.2010

    • Author(s)
      Masuda H, Oda H, Yoshimura Y, Maruyama T
    • Journal Title

      PLoS ONE volume 5(4)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] OCT4 expression in human uterine myometrial stem/progenitor cells.2010

    • Author(s)
      Ono M, Oda H, Yoshimura Y, Maruyama T
    • Journal Title

      Hum Reprod volume25(8)

      Pages: 2059-2067

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] OCT4 expression in human uterine myometrial stem/progenitor cells.2010

    • Author(s)
      Ono M, Oda H, et al.
    • Journal Title

      Hum Reprod.

      Volume: 25 Pages: 2059-2067

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Stem Cell-Like Properties of the Endometrial Side Population : Implication in Endometrial Regeneration.2010

    • Author(s)
      Masuda H, Oda H, et al.
    • Journal Title

      PLoS ONE.

      Volume: 5

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Stem cell-like properties of the endometrial Side population : implication in endometrial regeneration.2010

    • Author(s)
      Masuda H, Matsuzaki Y, Hiratsu E, Ono M, Nagashima T, Kajitani T, Arase T, Oda H, Uchida H, Asada H, lto M, Yoshimura Y, Maruyama T, Okano H
    • Journal Title

      PLoS ONE. 5

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Epigenetic Treatment in Assisted Human Embryo Implantation.2009

    • Author(s)
      Uchida H, Maruyama T, Oda H
    • Journal Title

      J.Mamm.Ova Res. volume26

      Pages: 116-121

    • NAID

      130004436751

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] The UDP-glucose recepter P2RY14 triggers innate mucosal immunity in the female reproductive tract by inducing IL-8.2009

    • Author(s)
      Arase T, Oda H, Maruyama T
    • Journal Title

      J Immunol. volume182

      Pages: 7074-7084

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Epigenetic Treatment in Assisted Human Embryo Implantation.2009

    • Author(s)
      Uchida H, Maruyama T, Kagami M, Oda H, Nishikawa S, Kajitani T, Asada H, Yoshimura Y
    • Journal Title

      J.Mamm.Ova Res. 26

      Pages: 116-121

    • NAID

      130004436751

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The UDP-glucose recepter P2RY14 triggers innate mucosal immunity in the female reproductive tract by inducing IL-8.2009

    • Author(s)
      Arase T, Uchida H, Kajitani T, Ono M, TamakiK, Oda H, Nishikawa S, Kagami M, Nagashima T, Masuda H, Asada H, Yoshimura Y, Maruyama T
    • Journal Title

      J Immunol. 182

      Pages: 7074-7084

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Activation of SRC kinase and phosphorylation of signal transducer and activator of transcription-5 are required for decidual transformation of human endometrial stromal cells.2008

    • Author(s)
      Nagashima T, Maruyama T, Oda H
    • Journal Title

      Endocrinology volume149

      Pages: 1227-1234

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Glycodelin blocks progression to S phase and inhibits cell growth : a possible progesterone-induced regulator for endometrial epithelial cell growth.2008

    • Author(s)
      Ohta K, Maruyama T, Oda H
    • Journal Title

      Molecular human reproduction volume14

      Pages: 17-22

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 【思春期の諸問題】排卵障害2008

    • Author(s)
      丸山哲夫, 小田英之, 西川明花, 各務真紀, 内田浩, 吉村泰典
    • Journal Title

      産科と婦人科 75巻

      Pages: 529-536

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 【産婦人科ホルモン療法マニュアル】生殖内分泌・不妊 無月経2008

    • Author(s)
      丸山哲夫, 小田英之, 吉村泰典
    • Journal Title

      産科と婦人科 75巻

      Pages: 8-14

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 【ホルモン療法 最近の話題】月経異常を伴う内分泌疾患2008

    • Author(s)
      内田浩, 小田英之, 吉村泰典
    • Journal Title

      産婦人科治療 96巻

      Pages: 163-168

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 妊娠子宮における子宮筋Side Population細胞の役割2008

    • Author(s)
      小野政徳, 丸山哲夫, 小田英之, 吉村泰典
    • Journal Title

      日本生殖内分泌学会雑誌 13巻

      Pages: 25-19

    • NAID

      10021262312

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 子宮内膜症・腺筋症由来疼痛に関連する遺伝子の発現解析2008

    • Author(s)
      梶谷宇, 丸山哲夫, 小田英之, 吉村泰典
    • Journal Title

      エンドメトリオージス研究会会誌 29巻

      Pages: 91-93

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Activation of SRC kinase and phosphorylation of signal transducer and activator of transcription-5 are required for decidual transformation of human endometrial stromal cells2008

    • Author(s)
      Nagashima T, Maruyama T, Uchida H, Kajitani T, Arase T, Ono M, Oda H, Kagami M, Masuda H, Nishikawa S, Asada H, Yoshimura Y
    • Journal Title

      Endocrinology 149

      Pages: 1227-1234

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Glycodelin blocks progression to S phase and inhibits cell growth : a possible progesterone-induced regulator for endometrial epithelial cell growth2008

    • Author(s)
      Ohta K, Maruyama T, Uchida H, Ono M, Nagashima T, Arase T, Kajitani T, Oda H, Morita M, Yoshimura Y
    • Journal Title

      Molecular human reproduction 14

      Pages: 17-22

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 【思春期の諸問題】排卵障害2008

    • Author(s)
      丸山哲夫, 小田英之, 西川明花, 各務真紀, 内田浩, 吉村泰典
    • Journal Title

      産科と婦人科 75

      Pages: 529-536

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 【産婦人科ホルモン療法マニュアル】生殖内分泌・不妊無月経2008

    • Author(s)
      丸山哲夫, 西川明花, 小田英之, 荒瀬透, 小野政徳, 各務真紀, 内田浩, 吉村泰典
    • Journal Title

      産科と婦人科 75

      Pages: 8-14

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 【ホルモン療法最近の話題】月経異常を伴う内分泌疾患2008

    • Author(s)
      内田浩, 荒瀬透, 小野政徳, 各務真紀, 小田英之, 西川明花, 丸山哲夫, 吉村泰典
    • Journal Title

      産婦人科治療 96

      Pages: 163-168

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 妊娠子宮における子宮筋Side Population細胞の役割2008

    • Author(s)
      小野政徳, 丸山哲夫, 梶谷宇, 内田浩, 荒瀬透, 各務真紀, 小田英之, 西川明花, 升田博隆, 長島隆, 太田邦明, 伊藤守, 浅田弘法, 岡野栄之, 松崎有未, 吉村泰典
    • Journal Title

      日本生殖内分泌学会雑誌 13

      Pages: 25-29

    • NAID

      10021262312

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 子宮内膜症・腺筋症由来疼痛に関連する遺伝子の発現解析2008

    • Author(s)
      梶谷宇, 丸山哲夫, 浅田弘法, 小野政徳, 荒瀬透, 小田英之, 西川明花, 内田浩, 吉村泰典
    • Journal Title

      エンドメトリオージス研究会会誌 29

      Pages: 91-93

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Possible involvemen t of endometrial stem/progenitor cells in the pathogenesis of endometriosis.2010

    • Author(s)
      Tetsuo Maruyama
    • Organizer
      The First Asian Conference on Endometriosis (ACE)
    • Place of Presentation
      Denver, USA
    • Related Report
      2010 Final Research Report
  • [Presentation] Prospective isolation and functional analysis of stem/progenitor cells from the human uterine myometrium.2010

    • Author(s)
      Masanori Ono
    • Organizer
      8th International Society for Stem Cell Reserch (ISSCR)
    • Place of Presentation
      San Francisco, CA USA
    • Related Report
      2010 Final Research Report
  • [Presentation] 〔招請講演〕Possible involvement of endometrial stem/progenitor cells in the pathogenesis of endocetriosis.2010

    • Author(s)
      Tetsuo Maruyama, Hideyuki Oda, et al.
    • Organizer
      The First Asian Conference on Endometriosis (ACE).
    • Place of Presentation
      Denver, USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] Prospective isolation and functional analysis of stem/progenitor cells from the human uterine myometrium.2010

    • Author(s)
      Masanori Ono, Hideyuki Oda, et al.
    • Organizer
      8th International Society for Stem Cell Research (ISSCR).
    • Place of Presentation
      San Francisco, CA USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] Up-regulation of 5-and 15-lipoxygenases in endometriosis.2009

    • Author(s)
      Takashi Kajitani
    • Organizer
      25th European Society of Human Reproduction and Embryology (ESHRE)
    • Place of Presentation
      Amsterdam, Netherlands
    • Related Report
      2010 Final Research Report
  • [Presentation] UDP-glucose and its receptor P2RY14 as a novel innate immunity in the female reproductive tract.2009

    • Author(s)
      Toru Arase
    • Organizer
      29th Ameican Society for Reproductive Immunology (ASRI)
    • Place of Presentation
      Orlando, Florida
    • Related Report
      2010 Final Research Report
  • [Presentation] The role of uterine smooth muscle stem cells, isolated based on cell surface markers, in myometrial remodeling in the pregnant uterus.2009

    • Author(s)
      Ono M
    • Organizer
      56th Society for Gynecologic Investigation
    • Place of Presentation
      Glasgow, Scotland
    • Related Report
      2010 Final Research Report
  • [Presentation] 表面抗原を用いたヒト子宮平滑筋幹細胞の新しい分離法の開発とその妊娠至急リモデリングにおける役割2009

    • Author(s)
      小野政徳
    • Organizer
      第8回 日本再生医療学会
    • Place of Presentation
      東京都千代田区
    • Related Report
      2010 Final Research Report
  • [Presentation] 子宮内膜症組織におけるリポキシゲナーゼ経路関連遺伝子の発現解析2009

    • Author(s)
      梶谷宇
    • Organizer
      第30回 日本エンドメトリオーシス学会
    • Place of Presentation
      宮城県仙台市
    • Related Report
      2010 Final Research Report
  • [Presentation] Up-regulation of 5- and 15-lipoxygenases in endometriosis.2009

    • Author(s)
      Takashi Kajitani, Tetsuo Maruyama, Hironori Asada, Akiko Yamasaki, Hideyuki Oda, Sayaka Nishikawa, Hiroshi Uchida, Yasunori Yoshimura
    • Organizer
      25th European Society of Human Reproduction and Embryology(ESHRE).
    • Place of Presentation
      Amsterdam, Netherlands
    • Related Report
      2009 Annual Research Report
  • [Presentation] UDP-glucose and its receptor P2RY14 as a novel innate immunity in the female reproductive tract.2009

    • Author(s)
      Toru Arase, Tetsuo Maruyama, Hiroshi Uchida, Takashi Kajitani, Sayaka Nishikawa, Hideyuki Oda, Maki Kagami, Hironori Asada, Yasunori Yoshimura
    • Organizer
      29th Ameican Society for Reproductive Immunology(ASRI)
    • Place of Presentation
      Orlando, Florida
    • Related Report
      2009 Annual Research Report
  • [Presentation] The role of uterine smooth muscle stem cells, isolated based on cell surface markers, in myometrial remodeling in the pregnant uterus2009

    • Author(s)
      Ono M, Maruyama T, Kajitani T, Uchida H, Oda H, Nishikawa S, Kagami M, Arase T, Nagashima T, Masuda H, Morikawa S, Mabuchi Y, Okano Y, Matsuzaki Y, Yoshimura Y
    • Organizer
      56th Society for Gynecologic Investigation
    • Place of Presentation
      Glasgow, Scotland
    • Related Report
      2008 Annual Research Report
  • [Presentation] 表面抗原を用いたヒト子宮平滑筋幹細胞の新しい分離法の開発とその妊娠至急リモデリングにおける役割2009

    • Author(s)
      小野政徳, 丸山哲夫, 梶谷宇, 内田浩, 荒瀬透, 小田英之, 西川明花, 各務真紀, 浅田弘法, 升田博隆, 岡野栄之, 松崎有未, 吉村泰典
    • Organizer
      第8回日本再生医療学会
    • Place of Presentation
      東京都千代田区
    • Related Report
      2008 Annual Research Report
  • [Presentation] 子宮内膜症組織におけるリポキシゲナーゼ経路関連遺伝子の発現解析2009

    • Author(s)
      梶谷宇, 丸山哲夫, 浅田弘法, 内田浩, 各務真紀, 小田英之, 西川明花, 山崎彰子, 吉村泰典
    • Organizer
      第30回日本エンドメトリオーシス学会
    • Place of Presentation
      宮城県仙台市
    • Related Report
      2008 Annual Research Report
  • [Presentation] 子宮内膜におけるP2RY14を介した新たな粘膜防御機構2008

    • Author(s)
      荒瀬透
    • Organizer
      第23回 日本生殖免疫学会
    • Place of Presentation
      富山県富山市
    • Related Report
      2010 Final Research Report
  • [Presentation] Chemial abortionの既往を有する反復流産患者の病院および妊娠転帰に関する検討2008

    • Author(s)
      西川明花
    • Organizer
      第53回 日本生殖医学会
    • Place of Presentation
      神戸市中央区
    • Related Report
      2010 Final Research Report
  • [Presentation] 子宮平滑筋幹細胞の新しい分離法とその機能解析2008

    • Author(s)
      小野政徳
    • Organizer
      第81回 日本内分泌学会学術総会
    • Place of Presentation
      青森県弘前市
    • Related Report
      2010 Final Research Report
  • [Presentation] 子宮平滑筋幹細胞の新しい分離法とその機能解析2008

    • Author(s)
      小野政徳, 丸山哲夫, 梶谷宇, 内田浩, 荒瀬透, 小田英之, 西川明花, 長島隆, 升田博隆, 馬渕洋, 森川暁, 岡野栄之, 松崎有未, 吉村泰典
    • Organizer
      第81回日本内分泌学会学術総会
    • Place of Presentation
      青森県弘前市
    • Related Report
      2008 Annual Research Report
  • [Presentation] 子宮内膜におけるP2RY14を介した新たな粘膜防御機構.2008

    • Author(s)
      荒瀬透, 丸山哲夫, 内田浩, 梶谷宇, 西川明花, 小田英之, 各務真紀, 浅田弘法, 吉村泰典
    • Organizer
      第23回日本生殖免疫学会
    • Place of Presentation
      富山県富山市
    • Related Report
      2008 Annual Research Report
  • [Presentation] Chemial abortionの既往を有する反復流産患者の病院および妊娠転帰に関する検討2008

    • Author(s)
      西川明花, 丸山哲夫, 小田英之, 各務真紀, 荒瀬透, 小野政徳, 長島隆, 内田浩, 吉村泰典
    • Organizer
      第53回日本生殖医学会
    • Place of Presentation
      神戸市中央区
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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