Cytokine Gene Expression Signature in Ovarian Cancer

• Project/Area Number: 20791170
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Obstetrics and gynecology
• Research Institution: Jikei University School of Medicine
• Principal Investigator: YANAIAHARA Nozomu Jikei University School of Medicine, 医学部, 助教 (20349624)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 婦人科腫瘍学 / 卵巣癌 / 遺伝子発現 / 予後予測 / 遺伝子発現解析

Research Abstract

Host defense against tumors are controlled by several immunological mediators including cytokines that play an important role in host-tumor immune system conflict. In this study, we sought to clarify whether the cytokine gene expression profile could have clinical association with ovarian cancer development and /or progression. We found that a cytokine gene expression signature of ovarian cancer could distinguish the histological subtypes and prognosis. A unique expression pattern found in ovarian clear cell adenocarcinoma might be involved in the pathogenesis of this subtype of ovarian cancer.

Research Products

• [Journal Article] Cyclin D1 predicts the prognosis of advanced serous ovarian cancer (2011)
  • Author(s): Hashimoto T, Yanaihara N, Okamoto A, Nikaido T, Saito M, Takakura S, Yasuda M, Sasaki H, Ochiai K, Tanaka T
  • Journal Title: Experimental and Therapeutic Medicine 2巻 Pages: 213-219
  • Peer Reviewed
• [Journal Article] Cyclin D1 predicts the prognosis of advanced serous ovarian cancer (2011)
  • Author(s): Hashimoto T, et al.
  • Journal Title: Experimental and Therapeutic Medicine. Volume: 2 Pages: 213-219
  • Peer Reviewed
• [Presentation] Cytokine Gene Expression Signature in Ovarian cancer (2010)
  • Author(s): Nozomu Yanaihara
  • Organizer: 13^<th> Biennial Meeting of the Internation al Gynecologic Cancer society
  • Place of Presentation: Prague
  • Year and Date: 2010-10-23
• [Presentation] Cytokine Gene Expression Signature in Ovarian cancer (2010)
  • Author(s): Nozomu Yanaihara
  • Organizer: 13^<th> Biennial Meeting of the International Gynecologic Cancer society
  • Place of Presentation: Prague(チェコ共和国)
  • Year and Date: 2010-10-23
• [Presentation] 上皮性卵巣癌における免疫関連遺伝子の発現解析 (2010)
  • Author(s): 矢内原臨
  • Organizer: 第62回日本産婦人科学会学術講演会
  • Place of Presentation: 東京
  • Year and Date: 2010-04-22