| Project/Area Number |
20791173
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Kurume University |
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Principal Investigator |
KAWANO Kouichiro Kurume University, 医学部, 助教 (10320160)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 婦人科腫瘍学 / 腫瘍免疫学 / がんワクチン / 婦人科腫瘍 / 免疫抑制 |
|---|
| Research Abstract |
We proposed an innovative strategy of cancer immunotherapy which not only activated the immune response but released from immune evasion in cervical cancer. In this study, infiltration of cytotoxic T lymphocytes (CTL) which had an important role for an elimination of tumor indicated a good prognosis. On the contrary, expression of pSTAT3 which affect an immune evasion associated with a poor prognosis. Although correlation between infiltration of CTL and the expression of pSTAT3 was not observed in this study, we verified that pSTAT3 up-regulated the production of the molecule which regress immune response such as VEGF and TGF-β in cervical cancer cell line. We expect the development of this innovative strategy for cancer immunotherapy by further investigation.
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