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The action points of genes induced by the glucocorticoids in acute sensorineural hearing loss.

Research Project

Project/Area Number 20791177
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Otorhinolaryngology
Research InstitutionUniversity of Tsukuba

Principal Investigator

HIROSE Yuki  University of Tsukuba, 附属病院, レジデント (00436049)

Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Keywords内耳性難聴 / ステロイド / アラキドン酸カスケード / 内耳保護効果 / 音響外傷
Research Abstract

The present findings suggest that glucocorticoid may exert protective effects against cochlear injury by binding glucocorticoid cytologic receptors, and that activation of cytologic phospholipase A2 may be involved in the generation of acoustic injury.

Report

(3 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • Research Products

    (2 results)

All 2009 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (1 results)

  • [Journal Article] Pharmacological strategies for cochlear protection and implication of glutamate and reactive oxygen species

    • Author(s)
      Keiji Tabuchi, Bungo Nishimura, Shuho Tanaka, Kentaro Hayashi, Yuki Hirose, Akira Hara Ischemia-reperfusion injury of the cochlea
    • Journal Title

      Current Neuropharmacology (Inpress)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Presentation] 音響外傷におけるグルココルチコイドとホスホリパーゼA2の保護効果2009

    • Author(s)
      廣瀬由紀, 田渕経司, 上前泊功, 飛田忠道, 辻茂希, 田中秀峰, 中山雅博, 原晃
    • Organizer
      日本耳鼻咽喉科学会
    • Place of Presentation
      ザ・プリンスパークタワー東京
    • Year and Date
      2009-05-16
    • Related Report
      2009 Annual Research Report 2009 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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