The neurophysiological study for elucidating the vestibular system

• Project/Area Number: 20791181
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Otorhinolaryngology
• Research Institution: The University of Tokyo
• Principal Investigator: CHIHARA Yasuhiro The University of Tokyo, 保健・健康推進本部, 助教 (20401060)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 耳科学 / 神経生理学 / 前庭 / 耳石器 / パッチクランプ / めまい平衡 / VEMP

Research Abstract

I developed the new clinical examination for otolith (oVEMP ; ocular vestibular evoked myogenic potentials). And I revealed the firing properties of vestibular ganglion neurons in vitro using patch-clamp technique.

Research Products

• [Journal Article] Frequency tuning properties of ocular vestibular evoked myogenic potentials. (2009)
  • Author(s): Chihara Y, Iwasaki S, Fujimoto C, Ushio M, Yamasoba T, Murofushi T
  • Journal Title: Neuroreport. 20 Pages: 1491-1495
  • Peer Reviewed
• [Journal Article] The firing properties of vestibular ganglion cells in heterozygous BDNF null mice. (2009)
  • Author(s): Chihara Y, Iwasaki S, Ito K, Yamasoba T, Nakamura S, Sahara Y
  • Journal Title: Neuroreport. 20 Pages: 1167-1171
  • Peer Reviewed
• [Journal Article] Ocular vestibular-evoked myogenic potentials (oVEMPs) require extraocular muscles but not facial or cochlear nerve activity. (2009)
  • Author(s): Chihara Y, Iwasaki S, Ushio M, Fujimoto C, Kashio A, Kondo K, Ito K, Asakage T, Yamasoba T, Kaga K, Murofushi T.
  • Journal Title: Clin Neurophysiol. 120 Pages: 581-587
  • Peer Reviewed
• [Journal Article] Fusiform aneurysm of the basilar artery presenting as a cerebellopontine angle mass. (2009)
  • Author(s): Chihara Y, Iwasaki S, Ushio M, Sugasawa K, Murofushi T.
  • Journal Title: Eur Arch Otorhinolaryngol. 266 Pages: 151-152
  • Peer Reviewed
• [Journal Article] Assessment of diagnostic accuracy of foam posturography for peripheral vestibular disorders: analysis of parameters related to visual and somatosensory dependence. (2009)
  • Author(s): Fujimoto C, Murofushi T, Chihara Y, Ushio M, Sugasawa K, Yamaguchi T, Yamasoba T, Iwasaki S.
  • Journal Title: Clin Neurophysiol. 120 Pages: 1408-1414
  • Peer Reviewed
• [Journal Article] The role of the superior vestibular nerve in generating ocular vestibular-evoked myogenic potentials to bone conducted vibration at Fz. (2009)
  • Author(s): Iwasaki S, Chihara Y, Smulders YE, Burgess AM, Halmagyi GM, Curthoys IS, Murofushi T
  • Journal Title: Clin Neurophysiol. 120 Pages: 588-593
  • Peer Reviewed
• [Journal Article] Fusiform aneurysm of the basilar artery presenting as a cerebellopontine angle mass (2009)
  • Author(s): Y.Chihara, et al.
  • Journal Title: European Archives Otorhinolaryngol 266 Pages: 151-152
  • Peer Reviewed
• [Journal Article] Frequency tuning properties of ocular vestibular evoked myogenic potentials (2009)
  • Author(s): Y.Chihara, et al.
  • Journal Title: Neuroreport 20 Pages: 1491-1495
  • Peer Reviewed
• [Journal Article] The firing properties of vestibular ganglion cells in heterozygous BDNF null mice (2009)
  • Author(s): Y.Chihara, et al.
  • Journal Title: Neuroreport 20 Pages: 1167-1171
  • Peer Reviewed
• [Journal Article] The role of the superior vestibular nerve in generating ocular vestibular-evoked myogenic potentials to bone conducted vibration at Fz (2009)
  • Author(s): S.Iwasaki, Y.Chihara, et al.
  • Journal Title: Clinical Neurophysiology 120 Pages: 588-593
  • Peer Reviewed
• [Journal Article] Assessment of diagnostic accuracy of foam posturography for peripheral vestibular disorders : analysis of parameters related to visual and somatosensory dependence (2009)
  • Author(s): C.Fujimoto, Y.Chihara, et al.
  • Journal Title: Clinical Neurophysiology 120 Pages: 1408-1414
  • Peer Reviewed
• [Journal Article] Ocular vestibular-evoked myogenic potentials(oVEMPs)require extraocular muscles but not facial or cochlear nerve activity (2009)
  • Author(s): Y. Chihara
  • Journal Title: Clinical Neurophysiology 120 Pages: 581-587
  • Peer Reviewed
• [Journal Article] Low-voltage-activated potassium channels underlie the regulation of intrinsic firing properties of rat vestibular ganglion cells. (2008)
  • Author(s): Iwasaki S, Chihara Y, Komuta Y, Ito K, Sahara Y.
  • Journal Title: J Neurophysiol. 100 Pages: 2192-2204
  • Peer Reviewed
• [Journal Article] Low-voltage-activated potassium channels underlie the regulation of intrinsic firi ng properties of rat vestibular ganglion cells (2008)
  • Author(s): S. Iwasaki, Y. Chihara (equally contribution)
  • Journal Title: J Neurophysiol 100 Pages: 2192-2204
  • Peer Reviewed
• [Presentation] ラット前庭神経節細胞における周波数応答の発達変化 (2009)
  • Author(s): 千原康裕
  • Organizer: 第68回日本めまい平衡医学会総会
  • Place of Presentation: 徳島
  • Year and Date: 2009-11-26
• [Presentation] Developmental changes in the frequency tuning properties of rat vestibular ganglion neurons (2009)
  • Author(s): 千原康裕
  • Organizer: 46th Inner Ear Biology Workshop
  • Place of Presentation: Utrecht(オランダ)
  • Year and Date: 2009-09-13
• [Presentation] Galvanic刺激被検者に認めた平衡機能検査の異常所見 (2009)
  • Author(s): 千原康裕
  • Organizer: 第110回日本耳鼻咽喉科学会総会
  • Place of Presentation: 東京
  • Year and Date: 2009-05-14
• [Presentation] Galvanic 刺激被検者に認めた平衡機能検査の異常所見 (2009)
  • Author(s): 千原康裕
  • Organizer: 第110回日本耳鼻咽喉科学会総会
  • Place of Presentation: 東京
  • Year and Date: 2009-05-14
• [Presentation] Vestibular dysfunction observed in subjects who underwent intense galvanic vestibular stimuli (2008)
  • Author(s): 千原康裕
  • Organizer: 第18回オーストラリア神経耳科学会
  • Place of Presentation: シドニー
  • Year and Date: 2008-11-02
• [Presentation] ラット前庭神経節細胞の神経栄養因子に対する反応性の変化 (2008)
  • Author(s): 千原康裕
  • Organizer: 第67回日本めまい平衡医学会総会
  • Place of Presentation: 秋田
  • Year and Date: 2008-10-30
• [Presentation] 音響刺激により眼周囲に記録される筋電位の起源に関する研究 (2008)
  • Author(s): 千原康裕
  • Organizer: 第3回ERA・OAE研究会(日本聴覚医学会)
  • Place of Presentation: 東京
  • Year and Date: 2008-07-06
• [Presentation] BDNFが前庭神経節細胞の発火特性に与える影響についての検討ノックアウトマウスを用いた解析 (2008)
  • Author(s): 千原康裕
  • Organizer: 第109回日本耳鼻咽喉科学会総会
  • Place of Presentation: 大阪
  • Year and Date: 2008-05-15
• [Presentation] :Frequency Tuning Properties of Ocular Vestibular Evoked Myogenic Potentials (2008)
  • Author(s): 千原康裕
  • Organizer: 第25回Barany Society Meeting
  • Place of Presentation: 京都
  • Year and Date: 2008-04-03
• [Presentation] Frequency Tuning Properties of Ocular Vestibular Evoked Mvogenic Potentials (2008)
  • Author(s): 千原康裕
  • Organizer: 第25回Baramy Society Meetimg
  • Place of Presentation: 京都
  • Year and Date: 2008-04-03