| Project/Area Number |
20791188
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Shinshu University |
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Principal Investigator |
FUKUOKA Hisakuni Shinshu University, 医学部附属病院, 助教 (90419391)
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| Co-Investigator(Renkei-kenkyūsha) |
USAMI Shinichi 信州大学, 医学部, 教授 (10184996)
KITO Ryousuke 信州大学, 医学部, 助教 (80419358)
NISHIO Shinya 信州大学, 医学部, 研究員 (70467166)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 遺伝子 / 難聴 / 内耳 / 聴覚 / 低音障害型感音難聴 / WFS1遺伝子 / 遺伝子発現パターン / レーザーマイクロダイセクション / 遺伝子発現 |
|---|
| Research Abstract |
Some diseases including Meniere's disease and acute low tone sensory neural hearing loss indicate typical clinical feature, low tone hearing loss. WFS1 gene mutation which reported as a genetic cause of autosomal dominant type low tone sensory neural hearing loss. In this study, we perform gene association study of Meniere's disease. We determine 12 reported Menisre's disease associated SNPs and WFS1 gene SNP for 100 Meniere's disease patients, but we cannot found any statistical significant SNPs.
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