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Bral2 is essential for the maintenance of the extracellular microenvironment for the synaptic transmission in the auditory system.

Research Project

Project/Area Number 20791195
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Otorhinolaryngology
Research InstitutionOkayama University

Principal Investigator

BEKKU Yoko  Okayama University, 医学部, 技術専門職員 (60397875)

Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords神経科学 / 聴覚伝導路 / 細胞外マトリックス / 神経細胞周囲網 / プロテオグリカン / リンクプロテイン
Research Abstract

There are two types of cells in the brain ; the neuronal cell and glial cell. Extracellular matrix (ECM), such as hyaluronan and proteoglycan, exists in extracellular region of these cells. There are two dense organized ECM in the brain, one is in the perineuronal net (PNN) and other is at the node of Ranvier. The PNN is a mesh like structure surrounding the neuronal cell. Bral2 forms ECM complex with hyaluronan and proteoglycan, and is localized in the PNN of the auditory system. In this study, it is strongly suggested that Brals play key roles in the ECM assembly and the complex is essential for the neuronal activity through the analysis of Bral - deficient mice

Report

(3 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • Research Products

    (18 results)

All 2010 2009 2008 Other

All Journal Article (6 results) (of which Peer Reviewed: 5 results) Presentation (9 results) Remarks (3 results)

  • [Journal Article] its role in diffusion barrier formation and conduction velocity in the CNS2010

    • Author(s)
      Bekku Y, Vargova L, Goto Y, Vorisek I, Dmytrenko L, Narasaki M, Ohtsuka A, Fassler R, Ninomiya Y, Sykova E, Oohashi T, Bral1
    • Journal Title

      J Neurosci 30(8)

      Pages: 3113-3123

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Brall : its role in diffusion barrier formation and conduction velocity in the CNS.2010

    • Author(s)
      Bekku, et al.
    • Journal Title

      J Neurosci 30

      Pages: 31133123-31133123

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Brevican organizes hyruronan-binding extracellular assemblies distinctively at the large diameter nodes of Ranvier in the CNS2009

    • Author(s)
      Bekku Y, Ninomiya Y, Oohashi T
    • Journal Title

      Neurosci Res 65

    • Related Report
      2009 Final Research Report
  • [Journal Article] Brevican distinctively assembles extracellular components at the large diameter nodes of Ranvier in the CNS2009

    • Author(s)
      Bekku Y, Rauch U, Ninomiya Y, Oohashi T
    • Journal Title

      J Neurochem 108(5)

      Pages: 1266-76

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Brevican distinctively assembles extracellular components at the large diameter nodes of Ranvier in the CNS.2009

    • Author(s)
      Bekku Y, et al.
    • Journal Title

      J Neurochem 108

      Pages: 1266-1276

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular cloning and developmental expression of a hyaluronan and proteoglycan link protein gene, crtl1/hapln1, in zebrafish2008

    • Author(s)
      Kang JS, Kawakami Y, Bekku Y, Ninomiya Y, Belmonte JCI, Oohashi T
    • Journal Title

      Zoological Science Vol25

      Pages: 912-918

    • NAID

      40016386641

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Presentation] Brevican organizes hyaluronan-binding extracellular assemblies distinctively at the large diameter nodes of Ranvier in the CNS2009

    • Author(s)
      Bekku Y, Rauch U, Ninomiya Y, Oohashi T
    • Organizer
      Neuroscience 2009第32回日本神経科学会大会
    • Place of Presentation
      名古屋
    • Related Report
      2009 Final Research Report
  • [Presentation] The nodal ECM barrier model in the CNS: From an extracellular ion diffusion analysis in Bral1-deficient mice2009

    • Author(s)
      Bekku Y, Vargova L, Goto Y, Vorisek I, Fassler R, Ninomiya Y, Sykova E, Oohashi T
    • Organizer
      Ninth Biennial Satellite Meeting of the ISN on Myelin Biology, Myelin Development, Function and Related Diseases Conference
    • Place of Presentation
      Gyeongju, S. Korea
    • Related Report
      2009 Final Research Report
  • [Presentation] The ion-diffusion barrier model at the node of Ranvier: From an extracellular ion diffusion analysis in Bral1-deficient mice2009

    • Author(s)
      Bekku Y, Vargova L, Goto Y, Ninomiya Y, Sykova E, Oohashi T
    • Organizer
      第36回国際生理学会大会
    • Place of Presentation
      京都
    • Related Report
      2009 Final Research Report
  • [Presentation] Brevican determines specialization of the hyaluronan-binding nodal matrix assemblies at the large diameter nodes of Ranvier in the CNS2009

    • Author(s)
      Bekku Y, Rauch U, Ninomiya Y, Oohashi T
    • Organizer
      第56回マトリックス研究会大会、8th Pan-Pacific Connective Tissue Society Symposium
    • Place of Presentation
      神奈川
    • Related Report
      2009 Final Research Report
  • [Presentation] The ion-diffusion barrier model at the node of Ranvier. From an extracellular ion diffusion analysis in Bral1-deficient mice2009

    • Author(s)
      別宮洋子
    • Organizer
      第36回国際生理学会大会
    • Place of Presentation
      京都国際会館
    • Related Report
      2009 Annual Research Report
  • [Presentation] The nodal ECM barrier model in the CNS : From an extracellular ion diffusion analysis in Brall-deficient mice2009

    • Author(s)
      別宮洋子
    • Organizer
      Ninth Biennial Satellite Meeting of the ISN on Myelin Biology, Myelin Development Function and Related Diseases Conference
    • Place of Presentation
      Gyeongju, S.Korea
    • Related Report
      2009 Annual Research Report
  • [Presentation] Btevican organizes hyalumnan-binding extracellular assemblies distinctively at the large diameter nodes of Ranvier in the CNS2009

    • Author(s)
      別宮洋子
    • Organizer
      Neuroscience 2009第32回日本神経科学会大会
    • Place of Presentation
      名古屋国際会議場
    • Related Report
      2009 Annual Research Report
  • [Presentation] Deletion of the brain-specific link protein Bral-1 facilitates extracellular diffusion in the mouse corpus callosum. and E. Sykova2008

    • Author(s)
      Vargova L, Dmytrenko L, Vorisek I, Bekku Y, Oohashi T
    • Organizer
      SfN 2008
    • Place of Presentation
      Washington DC, USA
    • Related Report
      2009 Final Research Report
  • [Presentation] Deletion of the brain-specific link protein Bral-1 facilitates extracellular diffusion in the mouse corpus callosum2008

    • Author(s)
      Vargova L, et al.
    • Organizer
      Neuroscience 2008
    • Place of Presentation
      Washington DC
    • Related Report
      2008 Annual Research Report
  • [Remarks] 岡山大学プレスリリース平成22年2月23日

    • Related Report
      2009 Final Research Report
  • [Remarks] 山陽新聞掲載平成22年3月16日

    • URL

      http://www.mbb-okayama.com/index.html

    • Related Report
      2009 Final Research Report
  • [Remarks]

    • URL

      http://www.mbb-okayama.com/index.html

    • Related Report
      2009 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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