Cytoskeletal analysis in control of pressure :its relationship to PPARγ expression

• Project/Area Number: 20791200
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Otorhinolaryngology
• Research Institution: Kyushu University
• Principal Investigator: SHIRATSUCHI Hideki Kyushu University, 大学病院, 助教 (30398060)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2008: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
• Keywords: PPARγ / cytoskelton / integrin / 中耳真珠腫 / 圧調節機構 / 先天性真珠腫 / 後天性真珠腫 / PPAR

Research Abstract

The following major progresses were submitted for publication.
1. The expression of integrin-related protein was different between congenital and acquired middle ear cholesteatoma.
2. The integin-related signaling was changed by pressure overload.
3. PPARγ was closely linked to integrin signaling.

Research Products

• [Journal Article] Close correlation between CXCR4 and VEGF expression and their prognostic implications in nasopharyngeal carcinoma. (2009)
  • Author(s): Segawa Y, Oda Y, Yamamoto H, Shiratsuchi H, Hirakawa N, Komune S, Tsuneyoshi M
  • Journal Title: Oncol Rep. 21(5) Pages: 1197-202
• [Journal Article] Close correlation between CXCR4 and VEGF expression and their prognostic implications in nasopharyngeal carcinoma. (2009)
  • Author(s): Shiratsuchi H, et.,al
  • Journal Title: Oncol Rep. 21(5) Pages: 1197-202
  • Peer Reviewed
• [Journal Article] Overexpression of inducible nitric oxide synthase and accumulation of 8-OHdG in nasopharyngeal carcinoma. (2008)
  • Author(s): Segawa Y, Oda Y, Yamamoto H, Uryu H, Shiratsuchi H, Hirakawa N, Tomita K, Yamamoto T, Oda S, Yamada T, Komune S, Tsuneyoshi M
  • Journal Title: Histopathology 52(2) Pages: 213-23
• [Journal Article] 真珠腫性中耳炎に対する乳突腔充填術後に生じた真珠腫再発について. (2008)
  • Author(s): 賀数康弘、松本希、白土秀樹、中島寅彦、君付隆、小宗静男
  • Journal Title: 頭頸部外科 17(3) Pages: 279-285
  • NAID: 10025712211
• [Journal Article] Overexpression of inducible nitric oxide synthase and accumulation of 8-OHdG in nasopharyngeal carcinoma (2008)
  • Author(s): H. Shiratsuchi, et.al
  • Journal Title: Histopathology 52 Pages: 213-223
  • Peer Reviewed
• [Journal Article] PPAR expression in middle ear cholesteatoma;Its roles in integrin expression and matrix invaion.
  • Author(s): Shiratsuchi H, Nakashima T, Komune N., Komune S.
  • Journal Title: Laryngoscope (In press)
• [Presentation] 耳管開放症症例における耳管機能検査の検討 (2009)
  • Author(s): 白土秀樹、村上大輔、君付隆、小宗静男
  • Organizer: 第19回日本耳科学会総会・学術講演会
  • Place of Presentation: 東京
• [Presentation] 当科における唾液腺癌の臨床病理学的検討 (2009)
  • Author(s): 白土秀樹、中島寅彦、安松隆治、門田英輝、古後龍之介、橋本和樹、小宗静男
  • Organizer: 第19回日本頭頸部外科学会総会・学術講演会
  • Place of Presentation: 名古屋
• [Presentation] 上咽頭癌に対するTS-1, Vitamina併用放射線化学療法(TAR療法)の治療成績 (2008)
  • Author(s): 白土秀樹、中島寅彦、橋本和樹、安松隆治、平川直也、小宗静男
  • Organizer: 第109回日本耳鼻咽喉科学会総会・学術講演会
  • Place of Presentation: 大阪