Analysis of mucosal immunity inducement system associated CCL20/CCR6 in upper respiratory tract

Research Project

Project/Area Number	20791204
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Otorhinolaryngology
Research Institution	Oita University
Principal Investigator	ABE Nobuyuki Oita University, 医学部, 助教 (10433054)
Project Period (FY)	2007 – 2009
Project Status	Completed (Fiscal Year 2009)
Budget Amount *help	¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000) Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords	鼻科学 / 上気道 / 粘膜免疫 / MIP-3α / CCL20 / 経鼻ワクチン / 樹状細胞 / ケモカイン
Research Abstract	BALB/c mice were immunized intranasally OVA and MIP-3α/CCL20. The dendritic cell was induced to NALT in the eminence for an immunohistochemistry . However, OVA specific immune response of IgG and IgA was not induced in the examination of ELISA. It was suggested not to have to the adjuvant effect in the passing nosal vaccine though MIP-3α/CCL20 was able to induce the dendritic cell from this to the immunity inducement tissue.

Report

(3 results)