Analysis of mucosal immunity inducement system associated CCL20/CCR6 in upper respiratory tract
Project/Area Number |
20791204
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
Otorhinolaryngology
|
Research Institution | Oita University |
Principal Investigator |
ABE Nobuyuki Oita University, 医学部, 助教 (10433054)
|
Project Period (FY) |
2007 – 2009
|
Project Status |
Completed (Fiscal Year 2009)
|
Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
|
Keywords | 鼻科学 / 上気道 / 粘膜免疫 / MIP-3α / CCL20 / 経鼻ワクチン / 樹状細胞 / ケモカイン |
Research Abstract |
BALB/c mice were immunized intranasally OVA and MIP-3α/CCL20. The dendritic cell was induced to NALT in the eminence for an immunohistochemistry . However, OVA specific immune response of IgG and IgA was not induced in the examination of ELISA. It was suggested not to have to the adjuvant effect in the passing nosal vaccine though MIP-3α/CCL20 was able to induce the dendritic cell from this to the immunity inducement tissue.
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Report
(3 results)
Research Products
(1 results)