| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Research Abstract |
We established the expression of insulin receptor in the olfactory mucosa by immunostaining method.
The calcineurin inhibition decreased specifically IRS-2 protein level by 50% in cultured bovine adrenal chromaffin cells, without changing IRS-2 mRNA level, and insulin receptor, insulin-like growth factor-I receptor, IRS-1, PI3K/PDK-1/Akt/GSK-3β and ERK1/ERK2 protein levels.
Additionally, we examined olfactory sensation of persons who had the long term exposure of arsenicum. The impaired sense of small was 51%, and the olfactory anesthesia was 22%.
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