| Project/Area Number |
20791207
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
KAMEKURA Ryuta Sapporo Medical University, 医学部, 研究員 (70404697)
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| Research Collaborator |
HIMI Tetsuo 札幌医科大学, 医学部, 教授 (90181114)
GO Mitsuru 札幌医科大学, 医学部, 講師 (80448604)
TAKANO Kenichi 札幌医科大学, 医学部, 助教 (70404689)
SAWADA Norimasa 札幌医科大学, 医学部, 教授 (30154149)
KOJIMA Takashi 札幌医科大学, 医学部, 准教授 (30260764)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | アレルギー / 病理学 / タイト結合 / 樹状細胞 / TSLP / 鼻粘膜 |
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| Research Abstract |
Thymic stromal lymphopoietin (TSLP) is an IL-7-like cytokine that triggers dendritic cell (DC)-mediated T helper 2-type inflammatory responses. TSLP is a master molecule for allergic inflammation such as that in asthma and atopic dermatitis. In the present study, we first found high expression of TSLP in the epithelium of allergic rhinitis with recruitment and infiltration of DCs. In human nasal epithelial cells in vitro TSLP was significantly induced by treatment with the proinflammatory cytokines and a Toll-like receptor ligand. Treatment with TSLP also enhanced the barrier function of tight junctions of human nasal epithelial cells in vitro and mouse DC line XS52 together with an increase of tight junction proteins.
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