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The role of dendritic cell-activating factor TSLP in allergic rhinitis

Research Project

Project/Area Number 20791207
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Otorhinolaryngology
Research InstitutionSapporo Medical University

Principal Investigator

KAMEKURA Ryuta  Sapporo Medical University, 医学部, 研究員 (70404697)

Research Collaborator HIMI Tetsuo  札幌医科大学, 医学部, 教授 (90181114)
GO Mitsuru  札幌医科大学, 医学部, 講師 (80448604)
TAKANO Kenichi  札幌医科大学, 医学部, 助教 (70404689)
SAWADA Norimasa  札幌医科大学, 医学部, 教授 (30154149)
KOJIMA Takashi  札幌医科大学, 医学部, 准教授 (30260764)
Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywordsアレルギー / 病理学 / タイト結合 / 樹状細胞 / TSLP / 鼻粘膜
Research Abstract

Thymic stromal lymphopoietin (TSLP) is an IL-7-like cytokine that triggers dendritic cell (DC)-mediated T helper 2-type inflammatory responses. TSLP is a master molecule for allergic inflammation such as that in asthma and atopic dermatitis. In the present study, we first found high expression of TSLP in the epithelium of allergic rhinitis with recruitment and infiltration of DCs. In human nasal epithelial cells in vitro TSLP was significantly induced by treatment with the proinflammatory cytokines and a Toll-like receptor ligand. Treatment with TSLP also enhanced the barrier function of tight junctions of human nasal epithelial cells in vitro and mouse DC line XS52 together with an increase of tight junction proteins.

Report

(3 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • Research Products

    (25 results)

All 2010 2009 2008

All Journal Article (18 results) (of which Peer Reviewed: 18 results) Presentation (7 results)

  • [Journal Article] Kamekura RThymic stromal lymphopoietin induces tight junction protein claudin-7 via NF-kappaB in dendritic cells.2010

    • Author(s)
      Kojima T, Takashima A, Koizumi J, Ogasawara N, Go M, Takano K, Murata M, Tanaka S, Ichimiya S, Himi T, Sawada N
    • Journal Title

      Histochem Cell Biol 133(3)

      Pages: 339-348

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Kamekura RPPARgamma agonists upregulate the barrier function of tight junctions via a PKC pathway in human nasal epithelial cells.2010

    • Author(s)
      Ogasawara N, Kojima T, Go M, Ohkuni T, Koizumi J, Masaki T, Murata M, Tanaka S, Fuchimoto J, Himi T, Sawada N
    • Journal Title

      Pharmacol Res 61(6)

      Pages: 489-498

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Thymic stromal lymphopoietin induces tight junction protein claudin-7 via NF-kappaB in dendritic cells.2010

    • Author(s)
      Kamekura R, et al.
    • Journal Title

      Histochem Cell Biol. 133(3)

      Pages: 339-348

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PPARgamma agonists upregulate the barrier function of tight junctions via a PKC pathway in human nasal epithelial cells.2010

    • Author(s)
      Ogasawara N, et al.
    • Journal Title

      Pharmacol Res. (In press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Kamekura RThymic stromal lymphopoietin enhances tight-junction barrier function of human nasal epithelial cells.2009

    • Author(s)
      Kojima T, Koizumi JI, Ogasawara N, Kurose M, Go M, Harimaya A, Murata M, Tanaka S, Chiba H, Himi T, Sawada N
    • Journal Title

      Cell Tissue Res 338(2)

      Pages: 283-293

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Kamekura RInduction of JAM-A during differentiation of human THP-1 dendritic cells.2009

    • Author(s)
      Ogasawara N, Kojima T, Go M, Fuchimoto J, Koizumi JI, Ohkuni T, Masaki T, Murata M, Tanaka S, Ichimiya S, Himi T, Sawada N
    • Journal Title

      Biochem Biophys Res Commun 389(3)

      Pages: 543-549

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] ヒト鼻粘膜の機能解析から見えてくること2009

    • Author(s)
      氷見徹夫, 郷充, 近藤敦, 高野賢一, 正木智之, 小泉純一, 亀倉隆太, 大國毅, 小笠原徳子, 小島隆, 澤田典均
    • Journal Title

      耳鼻咽喉科展望 52

      Pages: 9-18

    • NAID

      130004911712

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Thymic stromal lymphopoietin enhances tight-junction barrier function of human nasal epithelial cells.2009

    • Author(s)
      Kamekura R, et al.
    • Journal Title

      Cell Tissue Res. 338(2)

      Pages: 283-293

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Induction of JAM-A during differentiation of human THP-1 dendritic cells.2009

    • Author(s)
      Ogasawara N, et al.
    • Journal Title

      Biochem Biophys Res Commun. 389(3)

      Pages: 543-549

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ヒト鼻粘膜の機能解析から見えてくること.2009

    • Author(s)
      氷見徹夫, 他
    • Journal Title

      耳鼻咽喉科展望 52:補1

      Pages: 9-18

    • NAID

      130004911712

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of thymic stromal lymphopoietin (TSLP) in allergic rhinitis: Induction of tight junction proteins in nasal epithelial cells and dendritic cells by epithelial-derived TSLP.2008

    • Author(s)
      Takano K, Kojima T, Ogasawara N, Go M, Kikuchi S, Ninomiya T, Kurose M, Koizumi J,, Kojima T, Koizumi J, Ogasawara N, Kurose M, Takano K, Go M, Himi T, Sawada N
    • Journal Title

      Inflammation and Regeneration 28(3)

      Pages: 160-165

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression of tight junction proteins in epithelium including Ck20-positive M-like cells of human adenoids in vivo and in vitro.2008

    • Author(s)
      Koizumi J, Kojima T, Ogasawara N,, Murata M, Tanaka S, Chiba H, Himi T, Sawada N
    • Journal Title

      J Mol Histol 39(3)

      Pages: 265-273

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Protein kinase C enhances tight junction barrier function of human nasal epithelial cells in primary culture by transcriptional regulation.2008

    • Author(s)
      郷充, 小島隆,, Kurose M, Go M, Harimaya A, Murata M, Osanai M, Chiba H, Himi T, Sawada N
    • Journal Title

      Mol Pharmacol 74(2)

      Pages: 432-442

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 粘膜のバリアと抗原サンプリング-鼻粘膜を介した新しい治療戦略にむけて2008

    • Author(s)
      亀倉隆太, 小笠原徳子, 小泉純一, 黒瀬誠, 高野賢一, 澤田典均, 氷見徹夫
    • Journal Title

      耳鼻咽喉科展望 51

      Pages: 32-38

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression of thymic stromal lymphopoietin (TSLP) in allergic rhinitis : Induction of tight junction proteins in nasal epithelial cells and dendritic cells by epithelial- derived TSLP2008

    • Author(s)
      Kamekura R, et.al.
    • Journal Title

      Inflammation and Regeneration 28(3)

      Pages: 160-165

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of tight junction proteins in epithelium including Ck20-posi tive M-like cells of human adenoids in vivo and in vitro2008

    • Author(s)
      Takano K, et.al.
    • Journal Title

      J Mol Histol 39(3)

      Pages: 265-273

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Protein kinase C enhances tight junction barrier function of human nasal epithelial cells in primary culture by transcriptional regulation2008

    • Author(s)
      Koizumi J, et.al.
    • Journal Title

      Mol Pharmacol 74(2)

      Pages: 432-442

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 粘膜のバリアと抗原サンプリングー鼻粘膜を介した新しい治療戦略にむけて2008

    • Author(s)
      郷充他
    • Journal Title

      耳鼻咽喉科展望 51 : 補1

      Pages: 32-38

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] 鼻粘膜上皮におけるIL-25産生についての検討2010

    • Author(s)
      亀倉隆太
    • Organizer
      第28回日本耳鼻咽喉科免疫アレルギー学会
    • Place of Presentation
      福井市
    • Year and Date
      2010-02-19
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] 鼻粘膜上皮におけるIL-25産生についての検討2009

    • Author(s)
      亀倉隆太
    • Organizer
      第48回日本鼻科学会総会・学術講演会
    • Place of Presentation
      松江市
    • Year and Date
      2009-10-03
    • Related Report
      2009 Final Research Report
  • [Presentation] 鼻粘膜上皮におけるIL-25産生についての検討2009

    • Author(s)
      亀倉隆太
    • Organizer
      第48回 日本鼻科学会総会・学術講演会
    • Place of Presentation
      松江市
    • Year and Date
      2009-10-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] ヒト鼻粘膜上皮細胞と樹状細胞のタイト結合蛋白はthymic stromal lymphopoietinによって誘導される2009

    • Author(s)
      亀倉隆太
    • Organizer
      第110回日本耳鼻咽喉科学会総会・学術講演会
    • Place of Presentation
      東京都
    • Year and Date
      2009-05-16
    • Related Report
      2009 Final Research Report
  • [Presentation] ヒト鼻粘膜上皮細胞と樹状細胞のタイト結合蛋白はthymic stromallymphopoietinによって誘導される2009

    • Author(s)
      亀倉隆太
    • Organizer
      第110回日本耳鼻咽喉科学会総会・学術講演会
    • Place of Presentation
      東京都
    • Year and Date
      2009-05-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] ヒト鼻粘膜上皮細胞と樹状細胞のタイト結合蛋白はthymic stromal lymphopoietinによって誘導される2009

    • Author(s)
      亀倉隆太
    • Organizer
      第21回気道病態研究会
    • Place of Presentation
      東京都
    • Year and Date
      2009-02-07
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] アレルギー性鼻炎におけるThymic stromal lymphopoietin (TSLP)の役割2008

    • Author(s)
      亀倉隆太
    • Organizer
      第97回日本病理学会総会
    • Place of Presentation
      金沢市
    • Year and Date
      2008-05-15
    • Related Report
      2009 Final Research Report 2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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