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Basic research for mechanisms of mucus cell metaplasia in otitis media and sinusitis.

Research Project

Project/Area Number 20791212
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Otorhinolaryngology
Research InstitutionNagoya City University

Principal Investigator

NAKAMURA Yoshihisa  Nagoya City University, 大学院・医学研究科, 助教 (90360023)

Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords杯細胞化生 / Math1 / TNF-α / レチノイン酸 / EGFR / Tnf-α / TNF・α
Research Abstract

A key issue in otitis media (OM) is mucous cell metaplasia, a condition for hyperproduction of mucus in the middle ear mucosa and development of chronic OM. We demonstrated that Math1, a critical transcription factor for the development of mucous cells in the intestine, in the presence of pro-inflammatory cytokine (tumor necrotic factor alpha, TNF・) and retinoic acid (RA), promoted the differentiation of middle ear epithelial cells (MEECs) into mucus cells. RA strengthened the expression of Math1 via the epidermal growth factor receptor (EGFR) tyrosine kinase activity. A specific inhibitor for EGFR tyrosine kinase, AG1478, abrogated the Math1 expression and reduced mucus cell numbers. Math1 or EGFR tyrosine kinase should be the therapeutic molecular target for the OM.

Report

(3 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • Research Products

    (6 results)

All 2009

All Journal Article (1 results) Presentation (5 results)

  • [Journal Article] ヒト大腸杯細胞HT29-MTXにおける杯細胞マーカーの発現2009

    • Author(s)
      中村善久
    • Journal Title

      耳鼻咽喉科免疫アレルギー 27

      Pages: 117-118

    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] 腺癌を合併した副鼻腔内反性乳頭腫の一例2009

    • Author(s)
      中村善久
    • Organizer
      日本鼻科学会
    • Place of Presentation
      島根
    • Year and Date
      2009-10-02
    • Related Report
      2009 Annual Research Report
  • [Presentation] レチノイン酸による杯細胞分化誘導の機序2009

    • Author(s)
      中村善久
    • Organizer
      日本耳鼻咽喉科学会
    • Place of Presentation
      東京
    • Year and Date
      2009-05-14
    • Related Report
      2009 Annual Research Report
  • [Presentation] Math1 drives the differentiation of middle ear epithelial cells into mucous cells in vitro.2009

    • Author(s)
      Yoshihisa Nakamura
    • Organizer
      6th Extraordinary International Symposium on Recent Advances in Otitis Media
    • Place of Presentation
      韓国
    • Year and Date
      2009-05-06
    • Related Report
      2009 Final Research Report
  • [Presentation] Mathl drives the differentiation of middle ear epithelial cells into mucous cells in vitro.2009

    • Author(s)
      中村善久
    • Organizer
      6^<th> Extraordinary International Symposium on Recent Advances in Otitis Media
    • Place of Presentation
      韓国(ソウル)
    • Year and Date
      2009-05-06
    • Related Report
      2009 Annual Research Report
  • [Presentation] 肺炎球菌ペプチドグリカンーポリサッカライドによる中耳粘膜肺細胞化生2009

    • Author(s)
      中村善久
    • Organizer
      耳鼻咽喉科免疫アレルギー学会
    • Place of Presentation
      千葉
    • Year and Date
      2009-02-12
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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