A relationship between epithelial sodium absorption and eosinophilic inflammation

• Project/Area Number: 20791214
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Otorhinolaryngology
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: YASUDA Makoto Kyoto Prefectural University of Medicine, 医学研究科, 助教 (60433273)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 好酸球性炎症 / イオン輸送 / 培養細胞 / 培養上皮細胞

Research Abstract

The mechanism of cytokine secretion by IL-4 was investigated in cultured a human nasal polyp epithelial cells. The most secreted cytokine was RANTS, but eotaxin was not detected in our studies. Treatment of 100ng/ml IL-4 significantly increased RANTES secretion, and this activation was observed at 72 hours after treatment.