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Elucidation of inner ear inflammation and basic research of therapeutic strategy for hearing impairment with a blockade of interleukin 6

Research Project

Project/Area Number 20791226
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Otorhinolaryngology
Research InstitutionKeio University

Principal Investigator

若林 健一郎  Keio University, 北里研究所病院, 研究員 (40348743)

Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords難聴治療 / マクロファージ / インターロイキン6 / 炎症反応 / 聴力の改善 / 炎症 / 臨床応用
Research Abstract

For clinical application of hearing loss therapy noise-exposed mice were treated with MR16-1 and evaluated. Improved hearing was noted in noise-exposed mice treated with MR16-1. Histological analysis revealed the decrease in spiral ganglion neurons was ameliorated in the MR16-1-treated group. A remarkable reduction of activated cochlear macrophages in spiral ganglions compared to the control group was observed when treated with MR16-1.
Thus, MR16-1 had protective effects both functionally and pathologically for the noise-damaged cochlea. IL-6 blockade would be a feasible novel therapeutic strategy for hearing loss.

Report

(3 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • Research Products

    (13 results)

All 2010 2009 2008

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (10 results)

  • [Journal Article] Blockade of interleukin-6 signaling suppressed cochlear inflammatory response and improved hearing impairment in noise-damaged mice cochlea.2010

    • Author(s)
      Wakabayashi K, et al, (他10名、1番目)
    • Journal Title

      Neurosci Res. 66(4)

      Pages: 345-352

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Blockade of interleukin-6 signaling suppressed cochlear inflammatory response and improved hearing impairment in noise-damaed mice cochlea2010

    • Author(s)
      若林健一郎
    • Journal Title

      Neurosci Res 66(4)

      Pages: 345-352

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] GFAP aggregates in the cochlear nerve increase the noise vulnerability of sensory cells in the organ of Corti in the murine model of Alexander disease.2008

    • Author(s)
      Masuda M, Wakabayashi K, et al, (他6名、4番目)
    • Journal Title

      Neurosci Res. 62(1)

      Pages: 15-24

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Presentation] blockade of interleukin-6 signaling suppressed cochlear inflammatory response and improved hearing impairment in noise-damaged mice cochlea2010

    • Author(s)
      Kenichiro Wakabayashi
    • Organizer
      33rd The Association for Research in Otolaryngology
    • Place of Presentation
      California U.S.A.
    • Related Report
      2009 Final Research Report
  • [Presentation] Blockadeof interleukin-6 signaling suppressed cochlear inflammatory response and improved hearing impairment in noise-damaged mice cochlea2010

    • Author(s)
      若林健一郎
    • Organizer
      33st The Association for Research in Otolaryngology
    • Place of Presentation
      Anaheim, California, USA
    • Related Report
      2009 Annual Research Report
  • [Presentation] 音響外傷蝸牛に対するIL-6阻害剤を用いた難聴治療への応用2009

    • Author(s)
      若林健一郎
    • Organizer
      第54回日本聴覚医学会総会・学術講演会
    • Place of Presentation
      新横浜
    • Related Report
      2009 Final Research Report
  • [Presentation] 音響外傷蝸牛に対する抗インターロイキン6阻害剤の効果2009

    • Author(s)
      若林健一郎
    • Organizer
      第110回日本耳鼻咽喉科学会総会・学術講演会
    • Place of Presentation
      東京
    • Related Report
      2009 Final Research Report
  • [Presentation] 音響外傷蝸牛に対するインターロイキン6阻害剤の効果2009

    • Author(s)
      若林健一郎
    • Organizer
      第2回厚生労働省急性感音難聴調査研究班会議
    • Place of Presentation
      東京
    • Related Report
      2009 Final Research Report
  • [Presentation] 音響外傷蝸牛に対する抗インターロイキン6阻害剤の効果2009

    • Author(s)
      若林健一郎
    • Organizer
      第110回日本耳鼻咽喉科学会総会
    • Place of Presentation
      東京
    • Related Report
      2009 Annual Research Report
  • [Presentation] 音響外傷蝸牛に対するIL-6阻害剤を用いた難聴治療への応用2009

    • Author(s)
      若林健―郎
    • Organizer
      第54回日本聴覚医学会総会・学術講演会
    • Place of Presentation
      横浜
    • Related Report
      2009 Annual Research Report
  • [Presentation] 音響外傷モデルマウスにおける抗可溶型インターロイキン6受容体抗体の効果2008

    • Author(s)
      若林健一郎
    • Organizer
      第18回日本耳科学会総会
    • Place of Presentation
      神戸
    • Related Report
      2009 Final Research Report
  • [Presentation] 音響外傷モデルマウスにおける抗可溶型インターロイキン6受容体抗体の効果2008

    • Author(s)
      若林健一郎
    • Organizer
      第31回日本神経科学会
    • Place of Presentation
      東京
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] 音響外傷モデルマウスにおける抗可溶型インターロイキン6受容体抗体の効果2008

    • Author(s)
      若林健一郎
    • Organizer
      第18回耳科学会総会
    • Place of Presentation
      神戸
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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