Elucidation of inner ear inflammation and basic research of therapeutic strategy for hearing impairment with a blockade of interleukin 6

• Project/Area Number: 20791226
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Otorhinolaryngology
• Research Institution: Keio University
• Principal Investigator: 若林 健一郎 Keio University, 北里研究所病院, 研究員 (40348743)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 難聴治療 / マクロファージ / インターロイキン6 / 炎症反応 / 聴力の改善 / 炎症 / 臨床応用

Research Abstract

For clinical application of hearing loss therapy noise-exposed mice were treated with MR16-1 and evaluated. Improved hearing was noted in noise-exposed mice treated with MR16-1. Histological analysis revealed the decrease in spiral ganglion neurons was ameliorated in the MR16-1-treated group. A remarkable reduction of activated cochlear macrophages in spiral ganglions compared to the control group was observed when treated with MR16-1.
Thus, MR16-1 had protective effects both functionally and pathologically for the noise-damaged cochlea. IL-6 blockade would be a feasible novel therapeutic strategy for hearing loss.

Research Products

• [Journal Article] Blockade of interleukin-6 signaling suppressed cochlear inflammatory response and improved hearing impairment in noise-damaged mice cochlea. (2010)
  • Author(s): Wakabayashi K, et al, (他10名、1番目)
  • Journal Title: Neurosci Res. 66(4) Pages: 345-352
  • Peer Reviewed
• [Journal Article] Blockade of interleukin-6 signaling suppressed cochlear inflammatory response and improved hearing impairment in noise-damaed mice cochlea (2010)
  • Author(s): 若林健一郎
  • Journal Title: Neurosci Res 66(4) Pages: 345-352
  • Peer Reviewed
• [Journal Article] GFAP aggregates in the cochlear nerve increase the noise vulnerability of sensory cells in the organ of Corti in the murine model of Alexander disease. (2008)
  • Author(s): Masuda M, Wakabayashi K, et al, (他6名、4番目)
  • Journal Title: Neurosci Res. 62(1) Pages: 15-24
  • Peer Reviewed
• [Presentation] blockade of interleukin-6 signaling suppressed cochlear inflammatory response and improved hearing impairment in noise-damaged mice cochlea (2010)
  • Author(s): Kenichiro Wakabayashi
  • Organizer: 33rd The Association for Research in Otolaryngology
  • Place of Presentation: California U.S.A.
• [Presentation] Blockadeof interleukin-6 signaling suppressed cochlear inflammatory response and improved hearing impairment in noise-damaged mice cochlea (2010)
  • Author(s): 若林健一郎
  • Organizer: 33st The Association for Research in Otolaryngology
  • Place of Presentation: Anaheim, California, USA
• [Presentation] 音響外傷蝸牛に対するIL-6阻害剤を用いた難聴治療への応用 (2009)
  • Author(s): 若林健一郎
  • Organizer: 第54回日本聴覚医学会総会・学術講演会
  • Place of Presentation: 新横浜
• [Presentation] 音響外傷蝸牛に対する抗インターロイキン6阻害剤の効果 (2009)
  • Author(s): 若林健一郎
  • Organizer: 第110回日本耳鼻咽喉科学会総会・学術講演会
  • Place of Presentation: 東京
• [Presentation] 音響外傷蝸牛に対するインターロイキン6阻害剤の効果 (2009)
  • Author(s): 若林健一郎
  • Organizer: 第2回厚生労働省急性感音難聴調査研究班会議
  • Place of Presentation: 東京
• [Presentation] 音響外傷蝸牛に対する抗インターロイキン6阻害剤の効果 (2009)
  • Author(s): 若林健一郎
  • Organizer: 第110回日本耳鼻咽喉科学会総会
  • Place of Presentation: 東京
• [Presentation] 音響外傷蝸牛に対するIL-6阻害剤を用いた難聴治療への応用 (2009)
  • Author(s): 若林健―郎
  • Organizer: 第54回日本聴覚医学会総会・学術講演会
  • Place of Presentation: 横浜
• [Presentation] 音響外傷モデルマウスにおける抗可溶型インターロイキン6受容体抗体の効果 (2008)
  • Author(s): 若林健一郎
  • Organizer: 第18回日本耳科学会総会
  • Place of Presentation: 神戸
• [Presentation] 音響外傷モデルマウスにおける抗可溶型インターロイキン6受容体抗体の効果 (2008)
  • Author(s): 若林健一郎
  • Organizer: 第31回日本神経科学会
  • Place of Presentation: 東京
• [Presentation] 音響外傷モデルマウスにおける抗可溶型インターロイキン6受容体抗体の効果 (2008)
  • Author(s): 若林健一郎
  • Organizer: 第18回耳科学会総会
  • Place of Presentation: 神戸