Expression of Treg and Th17 Lymphocyte Subsets in Eosinophilic Chronic Rhinosinusitis

Research Project

Project/Area Number	20791230
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Otorhinolaryngology
Research Institution	Jikei University School of Medicine
Principal Investigator	ASAKA Daiya Jikei University School of Medicine, 医学部, 助教 (20317928)
Project Period (FY)	2008 – 2010
Project Status	Completed (Fiscal Year 2010)
Budget Amount *help	¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000) Fiscal Year 2010: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000) Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords	免疫学 / 好酸球性副鼻腔炎 / Treg / Th17
Research Abstract	The clinical feature of eosinophilic chronic rhinosinusitis is intense eosinophilic inflammation in nasal mucosa. The pathophysiology of eosinophilic chronic rhinosinusitis is poorly understood. We thought that unbalance of Th subsets is underlying in pahophisiolosy of eosinophilic chronic rhinosinusitis. The expression of IL-4(+)CD4(+)T cell and IFN-γ(+)CD4(+) T cell in eosinophilic chronic rhinosinusitis were up-regulated in both nasal mucosa and PBMC compare to chronic rhinosinusitis. These result suggest that hyperimmunoreactivity to pathogen may contribute to pathgenesis of eosinophilic chronic rhinosinusitis.

Report

(4 results)