Hearing mechanism of melanocyte in inner ear

• Project/Area Number: 20791232
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Otorhinolaryngology
• Research Institution: Chubu University
• Principal Investigator: IDA Michiru Chubu University, 生命健康科学研究所, 助教 (80393148)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 内耳 / 難聴 / 色素細胞 / Waardenburg症候群 / 遺伝子改変マウス / メラノサイト / 中間細胞 / 先天性難聴 / c-kit / Wv / 色素異常

Research Abstract

Waardenburg syndrome, an auditory-pigmentary syndrome, is caused by abnormal differentiation in melanocyte-related gene such as endothelin receptor B (Ednrb). In this study, the aim is an elucidation of hearing loss with pigmentation disorder and its therapeutic development. Ednrb-deficient mice (Ednrb-KO) were deafness and had a defect of melanocyte in inner ear and decrease of spiral ganglion cells. The hearing losses with neurodegeneration of spiral ganglion cells were improved by introducing an Ednrb transgene under control of the dopamine beta-hydroxylase promoter.

Research Products

• [Journal Article] c-Ret-mediated hearing loss in mice with Hirschsprung disease. (2010)
  • Author(s): Ohgami N, Ida-Eto M, Shimotake T, Sakashita N, Sone M, Nakashima T, Tabuchi K, Hoshino T, Shimada A, Tsuzuki T, Yamamoto M, Sobue G, Jijiwa M, Asai N, Hara A, Takahashi M, Kato M.
  • Journal Title: Proc Natl Acad Sci U S A. 20;107(29)(Epub) Pages: 13051-13056
  • Peer Reviewed
• [Journal Article] Reduction of brain injury in neonatal hypoxic-ischemic rats by intracere broventricular injection of neural stem/progenitor cells together with chondroitinase ABC (2008)
  • Author(s): Yoshiaki Sato, et.al.
  • Journal Title: Reprod.Sci 15 Pages: 613-620
  • Peer Reviewed
• [Presentation] 騒音暴露に対するマウスの感受性の検討 (2009)
  • Author(s): 伊田みちる、大神信孝、土本一輝、堀創二朗、山口碧、加藤昌志
  • Organizer: 第79回日本衛生学会総会
  • Place of Presentation: 北里大学白金キャンパス(東京)
  • Year and Date: 2009-03-31
• [Presentation] 騒音性・加齢性難聴を発症したマウス内耳におけるD型アミノ酸含有タンパク質の検出 (2009)
  • Author(s): 大神信孝、伊田みちる、藤井紀子、土本一輝、堀創二朗、山口碧、加藤昌志
  • Organizer: 第79回日本衛生学会総会
  • Place of Presentation: 北里大学白金キャンパス(東京)
  • Year and Date: 2009-03-31
• [Presentation] 騒音暴露に対するマウスの感受性の検討 (2009)
  • Author(s): 伊田みちる, 他
  • Organizer: 第78回日本衛生学会総会
  • Place of Presentation: 北里大学
  • Year and Date: 2009-03-31
• [Presentation] 騒音性・加齢性難聴を発症したマウス内耳におけるD型アミノ酸含有タンパク質の検出 (2009)
  • Author(s): 大神信孝, 他
  • Organizer: 第78回日本衛生学会総会
  • Place of Presentation: 北里大学
  • Year and Date: 2009-03-31
• [Presentation] 神経幹細胞を用いた新生児低酸素性虚血性脳症治療の可能性 (2008)
  • Author(s): 伊田みちる, 他
  • Organizer: 第44回日本周産期・新生児医学会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2008-07-14
• [Patent(Industrial Property Rights)] 難聴又は耳鳴りの予防・治療剤 (2009)
  • Inventor(s): 加藤昌志、大神信孝、伊田みちる、田口暢彦
  • Industrial Property Rights Holder: 中部大学
  • Industrial Property Number: 2009-185334
  • Filing Date: 2009-08-08