Prognosis assesment by quantitative RT-PCR analysis of chimeric Iμ/BCL6 tanscripts

• Project/Area Number: 20791233
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Otorhinolaryngology
• Research Institution: Osaka Medical College
• Principal Investigator: LEE Koutetsu Osaka Medical College, 医学部, 講師 (10368087)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000); Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 頭頸部外科学 / 悪性リンパ腫 / 免疫グロブリンBCL6転座 / キメラ転写産物 / RT-PCR

Research Abstract

The chimeric Ig-BCL6 transcripts found in normal human tonsil and spleen cells. The appearance of Ig/BCL6 chromosomal translocations was associated with the cells expressing germinal center B cell. This study showed higher grade of malignant lymphoma express much quantity of Ig/BCL6 transcripts.