How YB-1 expression of laryngeal carcinoma influence infiltration, metastasis and resistance for antineoplastic?

Research Project

Project/Area Number	20791237
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Otorhinolaryngology
Research Institution	Kurume University
Principal Investigator	MIHASHI Hiroyuki Kurume University, 医学部, 助教 (10441643)
Project Period (FY)	2008 – 2010
Project Status	Completed (Fiscal Year 2010)
Budget Amount *help	¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000) Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000) Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000) Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Keywords	耳鼻咽喉科学 / 病理学 / 免疫組織化学 / YB-1 / 唾液腺癌 / 喉頭癌
Research Abstract	In the laryngeal cancer, YB-1 expression in the nuclear was not prognostic marker and correlative to infiltration and metastasis. But in the salivary gland cancer, YB-1 expression in the nuclear was found in salivary duct carcinoma much more and correlated with lymph node metastasis, distant metastasis, HER2 and hormone receptor. The group of YB-1 expression in the nuclear was worse prognosis than the group of no expression. So we thought YB-1 expression in the salivary gland cancer is the biomarker which influence to tumor proliferation and metastasis.