Dry mouth after radiation therapy

Research Project

Project/Area Number	20791239
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Otorhinolaryngology
Research Institution	独立行政法人国立病院機構(東京医療センター臨床研究センター)
Principal Investigator	FUJIMAKI Youko 独立行政法人国立病院機構(東京医療センター臨床研究センター), 人工臓器・機器開発研究部 (80462894)
Project Period (FY)	2008 – 2010
Project Status	Completed (Fiscal Year 2010)
Budget Amount *help	¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000) Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000) Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000) Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords	頭頸部腫瘍 / 放射線治療 / 口腔乾燥症 / 口腔水分計 / 強度変調放射線治療(IMRT)
Research Abstract	To evaluate "Dry mouth after radiation therapy", we investigated patients who are suffering from oral cancer or pharyingeal cancer and take radiation therapy about (1) questionnaire (2) resting saliva test (3) stimulating test with chewing gum (4) oral checker (MucusIII) As a result, it became clear that a change for the worse of dry mouth was made more clearly after 3 month than just after radiation. In the difference between the way in the past of radiation therapy and Intensity Modulated Radiation Therapy (IMRT), the average amount of radiation of minimum side of the parotid glands tends to be less in IMRT than the way in the past. And it results in that the level of dry mouth is slighter in IMRT than the way in the past.