The mechanisms of ocular disease by light stimulation

• Project/Area Number: 20791245
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Ophthalmology
• Research Institution: Gunma University
• Principal Investigator: AKIYAMA Hideo Gunma University, 医学部, 講師 (60359586)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2008: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
• Keywords: 光障害 / 網膜 / VEGF / 加齢黄斑変性症 / 酸化ストレス / 光刺激 / ビタミンA

Research Abstract

Light stimulation can induce HSP70 and HSP27 gene expression in retina of Y79 cell retinoblastoma cells or mice at transcriptional level and protein level.

Research Products

• [Journal Article] Effect of Intravitreal Injection of High-Dose Bevacizumab in Monkey Eyes. (2009)
  • Author(s): Sakurai K, Akiyama H
  • Journal Title: Invest Ophthalmol Vis Sci.
  • Peer Reviewed
• [Journal Article] Notch signaling regulates the differentiation of bone marrow-derived cells into smooth muscle-like cells during arterial lesion formation. (2009)
  • Author(s): Doi H, Iso T, Shiba Y, Sato H, Yamazaki M, Oyama Y
  • Journal Title: Akiyama H Biochem Biophys Res Commun 381(4) Pages: 654-9
  • Peer Reviewed
• [Journal Article] EIAV vector-mediated co-delivery of Endostatin and Angiostatin driven by the RPE-specific VMD2 Promoter Inhibits Choroidal Neovascularization. (2008)
  • Author(s): Kachi S, Binley K, Yokoi K, Umeda N
  • Journal Title: Akiyama H Hum Gene Ther.
  • Peer Reviewed
• [Journal Article] Effects of intraocular irrigation with melphalan on rabbit retinas during vitrectomy. (2008)
  • Author(s): Shimoda Y, Hamano R, Ishihara K, Shimoda N, Hagimura N
  • Journal Title: Akiyama H Graefes Arch Clin Exp Ophthalmol 246(4) Pages: 501-8
  • Peer Reviewed
• [Presentation] 持続光刺激による網膜での Heat Shock Protein(HSP)遺伝子発現の検討 (2009)
  • Author(s): 秋山英雄
  • Organizer: 網膜硝子体学会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2009-12-04
• [Presentation] 持続光刺激による網膜でのHeat Shock Protein(HSP)遺伝子発現の検討 (2009)
  • Author(s): 秋山英雄
  • Organizer: 網膜硝子体学会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2009-12-01
• [Presentation] 網膜芽細胞腫Y79細胞に対する光刺激のVEGF遺伝子発現 (2008)
  • Author(s): 秋山英雄
  • Organizer: 網膜硝子体学会
  • Place of Presentation: 京都国際会議場(京都府)
  • Year and Date: 2008-11-30
• [Presentation] ビタミンAは脈絡膜新生血管を促進する (2008)
  • Author(s): 秋山英雄
  • Organizer: 第62回日本臨床眼科学会
  • Place of Presentation: 東京
  • Year and Date: 2008-10-26
• [Presentation] ビタミンaは眼新生血管の成長に関係がある (2008)
  • Author(s): 秋山英雄
  • Organizer: 日本臨床眼科学会
  • Place of Presentation: 東京フォーラム(東京都)
  • Year and Date: 2008-10-08