Investigation of Pathophysiology and Innovative Treatment for Macular Degeneration with Thermosensitive Liposome

• Project/Area Number: 20791249
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Ophthalmology
• Research Institution: Kyoto University
• Principal Investigator: TAMURA Hiroshi Kyoto University, 医学研究科, 助教 (40418760)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 黄斑変性 / リボソーム / 脈絡膜新生血管 / ポリープ状脈絡膜血管症 / 強度近視 / 近視性脈絡膜新生血管

Research Abstract

New findings of age-related macular degeneration or its relative disease such as central serous chorioretinopathy and choroidal neovascularization secondary to angioid streaks are found to understand the pathophysiologies of these desease. For more improvement in treatment for age-related macular degeneration, problems and comparative merits among the current treatments are also revealed. These accomplishments would be helpful for development of innovative treatment for age-related macular degeneration.

Research Products

• [Journal Article] estoration of outer segments of foveal photoreceptors after resolution of central serous chorioretinopathy. (2010)
  • Author(s): Ojima Y, Tsujikawa A, Yamashiro K, Ooto S, Tamura H, Yoshimura N.
  • Journal Title: Jpn J Ophthalmol. 54(1) Pages: 55-60
• [Journal Article] Thickness of photoreceptor layers in polypoidal choroida vasculopathy and central serous chorioretinopathy. (2010)
  • Author(s): Ooto S, Tsujikawa A, Mori S, Tamura H, Yamashiro K, Yoshimura N.
  • Journal Title: Graefe's Archive for Clinical and Experimental Ophthalmology
• [Journal Article] Punctate Hyperfluorescent Spots Associated with Central Serous Chorioretinopathy as Seen on Indocyanine Green Angiography. (2010)
  • Author(s): Tsujikawa A, Ojima Y, Yamashiro K, Ooto S, Tamura H, Nakagawa S, Yoshimura N.
  • Journal Title: Retina (Epub ahead of print)
• [Journal Article] Sterile Endophthalmitis after Intravitreal Injection of Bevacizumab Obtained from a Single Batch. (2010)
  • Author(s): Yamashiro K, Tsujikawa A, Oh H, Otani A, Tamura H, Ooto S, Iwama D, Yoshimura N.
  • Journal Title: Retina 30(3) Pages: 485-90
• [Journal Article] Prognostic Factors of Vitreous Hemorrhage Secondary to Exudative Age-related Macular Degeneration. (2010)
  • Author(s): Hasegawa T, Otani A, Ooto S, Tamura H, Yamashiro K, Tsujikawa A, Yoshimura N.
  • Journal Title: Am J Ophthalmol. 149(2) Pages: 322-329
  • NAID: 120001823762
• [Journal Article] Relationship between the distribution of pseudoxanthoma elasticum skin and mucous membrane lesions and cardiovascular involvement. (2010)
  • Author(s): Utani A, Tanioka M, Yamamoto Y, Taki R, Araki E, Tamura H, Miyachi Y.
  • Journal Title: J Dermatol 37(2) Pages: 130-6
  • NAID: 10027065685
• [Journal Article] Punctate Hyperfluorescent Spots Associated with Central Serous Chorioretinopathy as Seen on Indocyanine Green Angiography. (2010)
  • Author(s): Tsujikawa A, Ojima Y, Yamashiro K, Ooto S, Tamura H, et al.
  • Journal Title: Retina (In press)
  • Peer Reviewed
• [Journal Article] Restoration of outer segments of foveal photoreceptors after resolution of central serous (2010)
  • Author(s): Ojima Y, Tsujikawa A, Yamashiro K, Ooto S, Tamura H, et al.
  • Journal Title: Jpn J Ophthalmol 54 Pages: 55-60
  • Peer Reviewed
• [Journal Article] Thickness of photoreceptor layers in polypoidal choroida vasculopathy and central serous chorioretinopathy (2010)
  • Author(s): Ooto S, Tsujikawa A, Mori S, Tamura H, et al.
  • Journal Title: Graefe's Archive for Clinical and Experimental Ophthalmology (In press)
  • Peer Reviewed
• [Journal Article] ARMS2 (LOC387715) Variants in Japanese Patients with Exudative Age-related Macular Degeneration and Polypoidal Choroidal Vasculopathy. (2009)
  • Author(s): Gotoh N, Nakanishi H, Hayashi H, Yamada R, Otani A, Tsujikawa A, Yamashiro K, Tamura H, Saito M, Saito K, Iida T, Matsuda F, Yoshimura N.
  • Journal Title: Am J Ophthalmol. 147(6)
• [Journal Article] Central Retinal Sensitivity After Intravitreal Injection of Bevacizumab for Myopic Choroidal Neovascularization. (2009)
  • Author(s): Yodoi Y, Tsujikawa A, Nakanishi H, Otani A, Tamura H, Ojima Y, Hayashi H, Yoshimura N.
  • Journal Title: Am J Ophthalmol. 147(5)
• [Journal Article] Improved visualization of polypoidal choroidal vasculopathy lesions using spectral-domain optical coherence tomography. (2009)
  • Author(s): Ojima Y, Hangai M, Sakamoto A, Tsujikawa A, Otani A, Tamura H, Yoshimura N.
  • Journal Title: Retina. 29(1) Pages: 52-9
• [Journal Article] Improved visualization of polypoidal choroidal vasculopathy lesions using spectral-domain optical coherence tomography. (2009)
  • Author(s): Ojima Y, Hangai M, Sakamoto A, Tsujikawa A, Otani A, Tamura H, Yoshimura N.
  • Journal Title: Retina 29 Pages: 52-59
  • Peer Reviewed
• [Journal Article] ARMS2 (LOC387715) Variants in Japanese Patients with Exudative Age-related Macular Degeneration and Polypoidal Choroidal Vasculopathy. (2009)
  • Author(s): Gotoh N, Nakanishi H, Hayashi H, Yamada R, Otani A, Tsujikawa A, Yamashiro K, Tamura H, et al.
  • Journal Title: Am J Ophthalmol. 147 Pages: 1037-1041
  • Peer Reviewed
• [Journal Article] Relationship between the distribution of pseudoxanthoma elasticum skin and mucous membrane lesions and cardiovascular involvement. (2009)
  • Author(s): Utani A, Tanioka M, Yamamoto Y, Taki R, Araki E, Tamura H, Miyachi Y.
  • Journal Title: J Dermatol 37 Pages: 130-136
  • NAID: 10027065685
  • Peer Reviewed
• [Journal Article] Prognostic Factors of Vitreous Hemorrhage Secondary to Exudative Age-related Macular Degeneration. (2009)
  • Author(s): Hasegawa T, Otani A, Ooto S, Tamura H, et al.
  • Journal Title: Am J Ophthalmol. 149 Pages: 322-329
  • NAID: 120001823762
  • Peer Reviewed
• [Journal Article] Endophthalmitis after Intravitreal Injection of Bevacizumab Obtained from a Single Batch. (2009)
  • Author(s): Yamashiro K, Tsujikawa A, Oh H, Otani A, Tamura H, et al.
  • Journal Title: Retina 30 Pages: 485-490
  • Peer Reviewed
• [Journal Article] Central Retinal Sensitivity After Intravitreal Injection of Bevacizumab for Myopic Choroidal Neovascularization (2009)
  • Author(s): Yodoi Y, Tsujikawa A, Nakanishi H, Otani A, Tamura H, et.al
  • Journal Title: Am J Ophthalmol
  • Peer Reviewed
• [Journal Article] Macular polypoidal choroidal vasculopathy with a remote lesion. (2008)
  • Author(s): Tsujikawa A, Nakanishi H, Ojima Y, Iwama D, Tamura H, Otani A, Yoshimura N.
  • Journal Title: Clin Experiment Ophthalmol. 36(9) Pages: 817-23
• [Journal Article] Two-Year Results of Photodynamic Therapy for Choroidal Neovascularization in Young Patients. (2008)
  • Author(s): Fujisato K, Otani A, Sasahara M, Yodoi Y, Aikawa H, Tamura H, Tsujikawa A, Yoshimura N.
  • Journal Title: J Jpn Ophthalmol Soc. 112 Pages: 777-785
  • NAID: 10024370022
• [Journal Article] Two-Year Results of Photodynamic Therapy for Polypoidal Choroidal Vasculopathy. (2008)
  • Author(s): Kurashige Y, Otani A, Sasahara M, Yodoi Y, Tamura H, Tsujikawa A, Yoshimura N.
  • Journal Title: Am J Ophthalmol. 146(4) Pages: 513-519
  • Peer Reviewed
• [Journal Article] Macular Complications On The Border of An Inferior Staphyloma Associated with Tilted Disc Syndrome. (2008)
  • Author(s): Nakanishi H, Tsujikawa A, Gotoh N, Hayashi H, Iwama D, Tamura H, Otani A, Yoshimura N.
  • Journal Title: Retina. 28(10) Pages: 1493-501
  • Peer Reviewed
• [Journal Article] Photodynamic Therapy Combined with Low-dose Intravitreal Triamcinolone Acetonide for Age-related Macular Degeneration Refractory to Photodynamic Therapy Alone. (2008)
  • Author(s): Iwama D, Otani A, Sasahara M, Yodoi Y, Gotoh N, Tamura Tsujikawa A, Yoshimura N.
  • Journal Title: Br J Ophthalmol. 92(10) Pages: 1352-1356
  • Peer Reviewed
• [Journal Article] Polypoidal choroidal vasculopathy with drusen. (2008)
  • Author(s): Iwama D, Tsujikawa A, Sasahara M, Hirami Y, Tamura H, Yoshimura N.
  • Journal Title: Jpn J Ophthalmol. 52(2) Pages: 116-121
  • NAID: 10024153811
  • Peer Reviewed
• [Journal Article] Improved visualization of polypoidal choroidal vasculopathy lesions using spectral-domain optical coherence tomography (2008)
  • Author(s): Ojima Y, Hangai M, Sakamoto A, Tsujikawa A, Otani A, Tamura H, et.al
  • Journal Title: Retina 29 Pages: 52-59
  • Peer Reviewed
• [Journal Article] Two-Year Results of Photodynamic Therapy for Choroidal Neovascularization in Young Patients (2008)
  • Author(s): Fujisato K, Otani A, Sasahara M, Yodoi Y, Aikawa H, Tamura H, et.al.
  • Journal Title: J Jpn Ophthalmol Soc 112 Pages: 777-785
  • NAID: 10024370022
  • Peer Reviewed
• [Journal Article] Two-Year Results of Photodynamic Therapy for Polypoidal Choroidal Vasculopathy (2008)
  • Author(s): Kurashige Y, Otani A, Sasahara M, Yodoi Y, Tamura H, et.al
  • Journal Title: Am J Ophthalmol 146 Pages: 513-519
  • Peer Reviewed
• [Journal Article] Macular Complications On The Border of An Inferior Staphyloma Associated with Tilted Disc Syndrome (2008)
  • Author(s): Nakanishi H, Tsujikawa A, Gotoh N, Hayashi H, Iwama D, Tamura H, et.al
  • Journal Title: Retina 28 Pages: 1493-501
  • Peer Reviewed
• [Journal Article] Photodynamic Therapy Combined with Low-dose Intravitreal Triamcinolone Acetonide for Age-related Macular Degeneration Refractory to Photodynamic Therapy Alone (2008)
  • Author(s): Iwama D, Otani A, Sasahara M, Yodoi Y, Gotoh N, Tamura H, et.al
  • Journal Title: Br J Ophthalmol 92 Pages: 1352-1356
  • Peer Reviewed
• [Journal Article] Polypoidal choroidal vasculopathy with drusen (2008)
  • Author(s): Iwama D, Tsujikawa A, Sasahara M, Hirami Y, Tamura H, Yoshimura N
  • Journal Title: Jpn J Ophthalmol 52 Pages: 116-121
  • NAID: 10024153811
  • Peer Reviewed
• [Journal Article] Lack of inducible nitric oxide synthases attenuates leukocyteendothelial cell interactions in retinal microcirculation (2008)
  • Author(s): Iwama D, Miyahara S, Tamura H, Miyamoto K, Hirose F, Yoshimura N
  • Journal Title: Br J Ophthalmol 92 Pages: 694-698
  • Peer Reviewed
• [Presentation] 加齢黄斑変性に対するトリアムシノロン・bevacizumab併用光線力学療法 (2010)
  • Author(s): 大音壮太郎、辻川明孝、後藤謙元、岩間大輔、田村寛
  • Organizer: 日本眼科手術学会総会
  • Place of Presentation: 兵庫
  • Year and Date: 2010-01-23
• [Presentation] 補償光学適用走査レーザー検眼鏡による中心性漿液性網脈絡膜症の視細胞構造 (2009)
  • Author(s): 大音壮太郎、板谷正紀、尾島優美子、田村寛、山城健児、大谷篤史、辻川明孝、大島進(ニデック)、井上卓(浜松ホトニクス)、吉村長久
  • Organizer: 日本臨床眼科学会
  • Year and Date: 2009-10-09
• [Presentation] ARMS2遺伝子A69S多型の迅速検出キットの開発および加齢黄斑変性診療における臨床応用 (2009)
  • Author(s): 山城健児、後藤謙元、中西秀雄、林寿子、仲田勇夫、辻川明孝、大谷篤史、大音壮太郎、田村寛、三谷康正(ダナフォーム)、吉村長久
  • Organizer: 日本臨床眼科学会
  • Year and Date: 2009-10-09
• [Presentation] ポリープ状脈絡膜血管症への光線力学療法の治療効果とARMS2 A69S多型との相関 (2009)
  • Author(s): 林寿子、山城健児、中西秀雄、仲田勇夫、辻川明孝、大谷篤史、大音壮太郎、田村寛、吉村長久
  • Organizer: 日本臨床眼科学会
  • Place of Presentation: 福岡
  • Year and Date: 2009-10-09
• [Presentation] 網膜色素線条に生じた脈絡膜新生血管の特徴 (2009)
  • Author(s): 山城健児、中川聡子、辻川明孝、大谷篤史、田村寛、大音壮太郎、吉村長久
  • Organizer: 日本眼科学会総会
  • Year and Date: 2009-04-17
• [Presentation] ポリープ状脈絡膜血管症におけるARM32遺伝子の遺伝子型と臨床所見の検討 (2009)
  • Author(s): 林寿子、山城健児、後藤謙元、中西秀雄、大谷篤史、辻川明孝、田村寛、斉藤昌晃(福島県立医科大学)、斉藤国治(福島県立医科大学)、飯田知弘(福島県立医科大学)、吉村長久
  • Organizer: 日本眼科学会総会
  • Year and Date: 2009-04-16
• [Presentation] 中心性漿液性網脈絡膜症症例におけるインドシアニングリーン蛍光眼底造影上の点状過蛍光 (2009)
  • Author(s): 辻川明孝、尾島優美、中西秀雄、林寿子、中川聡子、後藤謙元、岩間大輔、山城健児、用村實、大音壮太郎、大谷篤史、吉村長久
  • Organizer: 日本眼科学会総会
  • Year and Date: 2009-04-16
• [Presentation] ポリープ状脈絡膜血管症におけるARM32遺伝子の遺伝子型と臨床所見の検討 (2009)
  • Author(s): 林寿子、山城健児、後藤謙元、中西秀雄、大谷篤史、辻川明孝、田村寛
  • Organizer: 日本眼科学会総会
  • Place of Presentation: 東京
  • Year and Date: 2009-04-16
• [Presentation] 網膜色素線条に生じた脈絡膜新生血管の特徴 (2009)
  • Author(s): 山城健児、中川聡子、辻川明孝、大谷篤史、田村寛
  • Organizer: 日本眼科学会総会
  • Place of Presentation: 東京
  • Year and Date: 2009-04-16
• [Presentation] 加齢黄斑変性に対するトリアムシノロン・bevacizumab併用光線力学療法 (2009)
  • Author(s): 大音壮太郎、辻川明孝、後藤謙元、岩間大輔、田村寛、山城健児、大谷篤史、吉村長久
  • Organizer: 日本眼科手術学会総会
  • Year and Date: 2009-01-23
• [Presentation] D-OCTにおけるポリープ状脈絡膜血管症と中心性漿液性網脈絡膜症の網膜構造 (2008)
  • Author(s): 大音壮太郎、辻川明孝、森哲、中川聡子、林寿子、尾島優美子、中西秀雄、岩間大輔、後藤謙元、田村寛、大谷篤史、吉村長久
  • Organizer: 日本網膜硝子体学会
  • Year and Date: 2008-11-27
• [Presentation] Lack of iNOS Attenuates Leukocyte-Endothelial Cell Interactions in Retinal Microcirculation. (2008)
  • Author(s): Iwama D, Miyahara S, Tamura IL Miyamoto K, Hirose F, Yoshimura N.
  • Organizer: The Association for Research in Vision and Ophthalmology.
  • Year and Date: 2008-04-28
• [Presentation] Lack of iNOS Attenuates Leukocyte-Endothelial Cell Interactions in Retinal Microcirculation (2008)
  • Author(s): Iwama D, Miyahara S, Tamura H, Mivamoto K. Hirose F, Yoshimura N
  • Organizer: The Association for Research in Vision and Ophthalmology
  • Place of Presentation: Fort Lauderdale
  • Year and Date: 2008-04-28
• [Presentation] 炎症時網膜での白血球動態におけるiNosの役割 (2008)
  • Author(s): 岩間大輔、宮原晋介、宮本和明、広瀬文隆、吉村長久
  • Organizer: 日本眼科学会総会
  • Year and Date: 2008-04-17
• [Book] 加齢黄斑変性 (2008)
  • Author(s): 吉村長久・辻川明孝・大谷篤史・田村寛
  • Publisher: 医学書院