The effect of MCP-1 on the pathogenesis of giant papillae formation of the conjunctiva in vernal keratoconjunctivitis

Research Project

Project/Area Number	20791255
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Ophthalmology
Research Institution	Yamaguchi University
Principal Investigator	FUJITSU Youichiro Yamaguchi University, 大学院・医学系研究科, 助教 (80448290)
Project Period (FY)	2008 – 2009
Project Status	Completed (Fiscal Year 2009)
Budget Amount *help	¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000) Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000) Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords	春季カタル / 巨大乳頭 / MCP-1 / アレルギー / 細胞増殖 / 細胞・組織 / シグナル伝達
Research Abstract	Vernal keratoconjunctivitis is characterized by giant papilla formation. Increased expression of MCP-1 was also reported in the conjunctiva of patients with vernal keratoconjunctivitis. Human conjunctival fibroblasts express CCR2, and MCP-1 stimulates both the proliferation of and the production of extracellular matrix proteins such as fibronectin, procollagen type I C-peptide and type III collagen, in the dose dependent manner by these cells through MAPK pathway.