Investigation of ambient oxygen concentration on cell proliferation, cell death, and cell function in corneal cells
| Project/Area Number |
20791256
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Ophthalmology
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| Research Institution | Yamaguchi University |
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Principal Investigator |
YANAI Ryoji Yamaguchi University, 医学部, 講師 (10346554)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 眼細胞生物学 / 環境酸素濃度 / アポトーシス / 角膜上皮細胞 / Akt / 高酸素 / 細胞死 / アポトーシス抑制シグナル / 細胞増殖 / シグナル伝達 / 細胞・組織 / 遺伝子 |
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| Research Abstract |
Hyperoxia inhibited the proliferation of, and induced death by apoptosis in cultured human corneal epithelial cells. However hypoxia did not affect cell proliferation or apoptosis in those cells. The wearing of a contact lens of low oxygen permeability affected in the pattern of ZO-1. In contrast, the wearing of a rigid gas permeable contact lens did not affect in the pattern of ZO-1. Though sufficient supply of oxygen to corneal epithelium contributes stability of the epithelial barrier of corneal epithelium, hyperoxia over 21% oxygen affects corneal epithelium.
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Report
(3 results)
Research Products
(10 results)
