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Investigation of ambient oxygen concentration on cell proliferation, cell death, and cell function in corneal cells

Research Project

Project/Area Number 20791256
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Ophthalmology
Research InstitutionYamaguchi University

Principal Investigator

YANAI Ryoji  Yamaguchi University, 医学部, 講師 (10346554)

Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords眼細胞生物学 / 環境酸素濃度 / アポトーシス / 角膜上皮細胞 / Akt / 高酸素 / 細胞死 / アポトーシス抑制シグナル / 細胞増殖 / シグナル伝達 / 細胞・組織 / 遺伝子
Research Abstract

Hyperoxia inhibited the proliferation of, and induced death by apoptosis in cultured human corneal epithelial cells. However hypoxia did not affect cell proliferation or apoptosis in those cells. The wearing of a contact lens of low oxygen permeability affected in the pattern of ZO-1. In contrast, the wearing of a rigid gas permeable contact lens did not affect in the pattern of ZO-1. Though sufficient supply of oxygen to corneal epithelium contributes stability of the epithelial barrier of corneal epithelium, hyperoxia over 21% oxygen affects corneal epithelium.

Report

(3 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • Research Products

    (10 results)

All 2009 2008

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (4 results)

  • [Journal Article] Disruption of zonula occludens-1 localization in the rabbit corneal epithelium by contact lens-induced hypoxia2009

    • Author(s)
      Yanai R, Ko JA, Morishige N, Chikama T, Ichijima H, Nishida T
    • Journal Title

      Invest Ophthalmol Vis Sci. 50

      Pages: 4605-4610

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Disruption of zonula occludens-1 localization in the rabbit corneal epithelium by contact lens-induced hypoxia2009

    • Author(s)
      Yanai R
    • Journal Title

      Investigative Ophthalmology and Visual Science 50

      Pages: 4605-4610

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of ambient oxygen concentration on the proliferation and viability of cultured human corneal epithelial cells2008

    • Author(s)
      Yanai R, Liu Y, Ko JA, Nishida T
    • Journal Title

      Exp Eye Res 86

      Pages: 412-418

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of Ambient Oxygen Concentration on the Proliferation and Viability of Cultured Human Corneal Epithelial Cells2008

    • Author(s)
      Yanai R
    • Journal Title

      Experimental Eye research 86

      Pages: 412-418

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] オルソケラトロジー2008

    • Author(s)
      柳井亮二
    • Journal Title

      臨床眼科 62

      Pages: 1221-1226

    • NAID

      40016218163

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] コンタクトレンズ診療における生体角膜検査2008

    • Author(s)
      柳井亮二
    • Journal Title

      日本コンタクトレンズ学会誌 50

      Pages: 24-29

    • NAID

      10021293352

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] コンタクトレンズ関連感染性角膜炎の傾向と対策2009

    • Organizer
      中国・四国眼科スタッフ教育講習会
    • Place of Presentation
      山口市
    • Year and Date
      2009-11-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] Up-Regulation of ZO-1 in Cultured Human Corneal Epithelial Cells by re-oxygenation.2009

    • Author(s)
      Yanai R, Nishida T
    • Organizer
      The 4th International meeting of Clinical and Research Colloquium in Ophthalmology
    • Place of Presentation
      Yamaguchi, Japan
    • Year and Date
      2009-03-20
    • Related Report
      2009 Final Research Report
  • [Presentation] 再酸素化による角膜上皮細胞のZO-1発現に対する影響2009

    • Author(s)
      柳井亮二, 権伍勇, 高知愛, 近間泰一郎, 西田輝夫
    • Organizer
      第33回角膜カンファランス・第25回日本角膜移植学会
    • Place of Presentation
      大阪府
    • Year and Date
      2009-02-19
    • Related Report
      2009 Final Research Report
  • [Presentation] Myth. 1コンタクトレンズは就寝時装用してはいけない2008

    • Author(s)
      柳井亮二
    • Organizer
      第51回日本コンタクトレンズ学会総会
    • Place of Presentation
      福岡県
    • Year and Date
      2008-07-06
    • Related Report
      2009 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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