Analysis for function and pathology in retina stimulated by blue light using gene mutated age-related macular degeneration model mice

• Project/Area Number: 20791270
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Ophthalmology
• Research Institution: Keio University
• Principal Investigator: KOIZUMI Haruna Keio University, 医学部, 研究員 (70465011)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 網膜光障害 / 網膜電図 / 視細胞 / 酸化ストレス

Research Abstract

Several epidemiological or in vitro studies have shown that blue light in visible light reaching retina may disturb photoreceptors and cause age-related macular degeneration. However, phototoxicity after cataract surgery is still unknown especially in vivo. In current study, we established a novel murine intraocular lens implantation model and revealed that suppression of blue light (400-500nm) in addition to ultra violet prevented light-induced retinal degeneration in vivo.

Research Products

• [Journal Article] Retinal phototoxicity in a novel murine model of intraocular lens implantation (2009)
  • Author(s): Kurihara T, Omoto M, Noda K, Ebinuma M, Kubota S, Koizumi H, Yoshida S, Ozawa Y, Shimmura S, Ishida S, Tsubota K.
  • Journal Title: Mol Vis. 15 Pages: 2751-61
  • Peer Reviewed
• [Journal Article] Retinal phototoxicity in a novel murine model of intraocular lens implantation. (2009)
  • Author(s): Kurihara T, Koizumi H, et al.
  • Journal Title: Molecular Vision 15 Pages: 2751-2761
  • Peer Reviewed
• [Remarks]
  • URL: http://www.keio-eye.net/