Involvement of hyaluronan and its receptor CD44 with choroidal neovascularization

• Project/Area Number: 20791271
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Ophthalmology
• Research Institution: Keio University
• Principal Investigator: KOTO Takashi Keio University, 医学部, 助教 (60464814)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 脈絡膜血管新生 / 加齢黄斑変性 / CD44 / ヒアルロン酸 / 脈絡膜新生血管 / 炎症

Research Abstract

Pathogene si s of chor oidal neov ascular izat ion involve s mac r ophage ac t ivati on. On the other hand, extr ac el lular matr ix, such as hyalur onan, r egulate s mac r ophage s ac cumulat ion. We r eveal ed that the hyalur onan - CD44 signal ing i s invo lved in the generat ion of chor oidal neovascular i zat ion.

Research Products

• [Journal Article] Involvement of hyaluronan and its receptor CD44 with choroidal neovascularization (2009)
  • Author(s): Mochimaru H, Takahashi E, Tsukamoto N, Miyazaki J, Yaguchi T, Koto T, Kurihara T, Noda K, Ozawa Y, Ishimoto T, Kawakami Y, Tanihara H, Saya H, Ishida S, Tsubota K.
  • Journal Title: Invest Ophthalmol Vis Sci 50(9) Pages: 4410-5
  • Peer Reviewed
• [Journal Article] Involvement of hyaluronan and its receptor CD44 with choroidal neovascularization (2009)
  • Author(s): Koto T, et al
  • Journal Title: Invest Ophthalmol Vis Sci. 9 Pages: 4410-4415
  • Peer Reviewed
• [Presentation] 接着分子CD44の脈絡膜新生血管における関与 (2009)
  • Author(s): 持丸博史、厚東隆志, ら
  • Organizer: 第43回眼炎症学会
  • Place of Presentation: 大阪
  • Year and Date: 2009-07-10
• [Presentation] ヒアルロン酸およびヒアルロン酸受容体CD44の脈絡膜新生血管における関与 (2009)
  • Author(s): 持丸博史、高橋枝里、厚東隆志、野田航介、小沢洋子、谷原秀信、佐谷秀行、石田晋、坪田一男
  • Organizer: 第43回眼炎症学会
  • Place of Presentation: 大阪