Search for the mechanism of corneal epithelium stem cell deficiency by bullous keratopathy

Research Project

Project/Area Number	20791275
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Ophthalmology
Research Institution	Keio University
Principal Investigator	UCHINO Yuichi Keio University, 医学部, 助教 (80365337)
Project Period (FY)	2008 – 2009
Project Status	Completed (Fiscal Year 2009)
Budget Amount *help	¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000) Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords	水疱性角膜症 / 角膜上皮幹細胞 / 角膜輪部機能不全 / 幹細胞疲弊 / 幹細胞疲弊(stem cell deficiency)
Research Abstract	We could create a rabbit model of bullous keratopathy, by removal of the rabbit corneal endothelium, causing a artificial bullous keratopathy. Our result suggested that the bullous keratopathy increased turnover of the corneal epithelium. The long-term bullous keratopathy may produce the corneal epithelial stem cell depletion and limbal dysfunction.

Report

(3 results)