| Project/Area Number |
20791277
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Ophthalmology
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| Research Institution | Hokkaido University (2009)
Keio University (2008) |
|---|
Principal Investigator |
NODA Kousuke Hokkaido University, 大学院・医学研究科, 講師 (90296666)
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| Project Period (FY) |
2008 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2008: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
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| Keywords | 白血球接着分子 / 白血球ローリング / 白血球接着 / 糖尿病網膜症 / ICAM-1 / LFA-1 / Mac-1 |
|---|
| Research Abstract |
The purpose of this study is to determine whether the function of LFA-1 and Mac-1, both of which are the counter-receptors for ICAM-1, is upregulated in an animal model of early phase of diabetic retinopathy induced by streptozotocin (STZ). The data provided no evidence showing functional upregulation of LFA-1 and Mac-1. However, PSGL-1, counter-receptor for P-selectin, seemed to be upregulated in STZ-induced diabetic animal model. The current data indicates the functional change of PSGL-1 in chronic inflammation such as diabetes.
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