Proteomic analysis of the disease specific autoantibodies in Behcet's disease
| Project/Area Number |
20791279
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Ophthalmology
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| Research Institution | Tokyo Medical University |
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Principal Investigator |
OKUNUKI Yoko Tokyo Medical University, 医学部, 助教 (40459508)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | プロテオミクス / 内因性ぶどう膜炎 / 自己抗原 / ぶどう膜炎 / 自己免疫 / 網膜抗原 |
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| Research Abstract |
A proteomic approach combined with western blotting was applied to detect multiple retinal autoantigens in endogenous uveitis. As results, Esterase D and brain type creatine kinase were defined as retinal autoantigens in endogenous uveitis, including Behcet's disease, sarcoidosis, and Vogt-Koyanagi-Harada disease. There was no disease specificity in the two newly defined autoantigens.
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Report
(3 results)
Research Products
(23 results)
