| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
|
|---|
| Research Abstract |
Ectodomain shedding is defined as the disintegration and extracellular release of membranous protein on the cell surface. This cellular process plays a role both in the activation and inactivation of the shedding substrate of shedding, and can potentially change functional characteristics of the substrate. In the cornea, we elucidated that ectodomain shedding is mainly activated in corneal epithelium, and soluble form of TNFR1 and IL-6R is produced from corneal epithelium. We speculated that this process plays an indispensable role in corneal wound healing and reducing inflammatory reactions.
|
