| Project/Area Number |
20791295
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pediatric surgery
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| Research Institution | Tohoku University |
|---|
Principal Investigator |
HIDEYUKI Sasaki Tohoku University, 病院, 講師 (40438461)
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| Project Period (FY) |
2008 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 胆道閉鎖症 / 肝内胆管 / cDNA microarray / 免疫応答 / 副刺激 / 肝臓 / 動物モデル / 遺伝子発現プロファイル / 晩期合併症 / 長期予後 |
|---|
| Research Abstract |
In this study, animal model of biliary atresia was established by extrahepatic bile duct ligation, poly I : C intra-peritoneal injection. Liver specimens from these models were applied for cDNA microarray. Interestingly, increasing mRNA expression were detected 1227 genes, including inflammation related gene and apotosis related genes,
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