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Molecular-biological study for clarifying the etiology of lung hypoplasia of Gja1 knockout mice

Research Project

Project/Area Number 20791300
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Pediatric surgery
Research InstitutionKyushu University

Principal Investigator

NAGATA Kouji  Kyushu University, 大学院・医学研究院・小児外科学分野, 助教 (20419568)

Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords小児呼吸器外科学 / Gja1 / connexin43 / 肺低形成 / 肺発達 / IGF / ニトロフェン / 横隔膜ヘルニア / Gja-1 / gap junction / 低形成肺
Research Abstract

Gja1 (Cx43) knockout mice die after birth due to hypoplastic lungs. Adult hetero Cx43 mice were mated. Newborn mice were divided into the wild group and the knockout group. H.E. staining in the knockout mice showed narrow airspaces and thicker interalveolar septae. The m-RNA expression of AQP-5, Sp-C and a-SMA was significantly lower in knockout mice than that in the wild mice. Immunohistochemical staining in all markers (AQP-5, Sp-C and a-SMA) showed the same result to the m-RNA expression.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (45 results)

All 2011 2010 2009 2008

All Journal Article (19 results) (of which Peer Reviewed: 9 results) Presentation (26 results)

  • [Journal Article] Effect of insulin like growth factors on lungdevelopment in a nitrofen induced CDH model rat.2010

    • Author(s)
      Esumi G, Masumoto K, Teshiba R, Nagata K, Taguchi Tomoaki, et al.
    • Journal Title

      Pediatr Surg Int. 27

      Pages: 187-192

    • Related Report
      2010 Final Research Report
  • [Journal Article] Identification of TCTE3 as a gene responsible for congenital diaphragmatic hernia using a high-resolution single-nucleotide polymorphism array.2010

    • Author(s)
      Teshiba R, Masumoto K, Esumi G, Nagata K, Tomoaki Taguchi, et al.
    • Journal Title

      Pediatr Surg Int. 27

      Pages: 193-198

    • Related Report
      2010 Final Research Report
  • [Journal Article] Effect of insulin like growth factors on lungdevelopment in a nitrofen induced CDH model rat.2010

    • Author(s)
      Esumi G, Masumoto K, Teshiba R, Nagata K, et al.
    • Journal Title

      Pediatric Surgery International

      Volume: 27 Pages: 187-192

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of TCTE3 as a gene responsible for congenital diaphragmatic hernia using a high-resolution single-nucleotide polymorphism array2010

    • Author(s)
      Teshiba R, Masumoto K, Esumi G, Nagata K, et al.
    • Journal Title

      Pediatric Surgery International

      Volume: 27 Pages: 193-198

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Outcome and treatment in an antenatally diagnosed CCAM of the lung.2009

    • Author(s)
      Nagata K, Masumoto K, Tesiba R, Esumi G, Tsukimori K, Wake N, Taguchi T.
    • Journal Title

      Pediatr Surg Int 25

      Pages: 753-757

    • Related Report
      2010 Final Research Report
  • [Journal Article] 新生児腸間膜裂孔ヘルニアの1例2009

    • Author(s)
      永田公二、増本幸二、田尻達郎、田口智章
    • Journal Title

      日本小児外科学会雑誌 45

      Pages: 1055-1059

    • Related Report
      2010 Final Research Report
  • [Journal Article] Cx43 play important roles in the lung development.2009

    • Author(s)
      Kouji Nagata, Kouji Masumoto, Risa Tesiba, Genshirou Esumi, Keigo Yoshizaki, Satoshi Fukumoto, Kazuaki Nonaka, Tomoaki Taguchi.
    • Journal Title

      J Pediatr Surg 44

      Pages: 2296-2301

    • Related Report
      2010 Final Research Report
  • [Journal Article] 当科にて経験した超低出生体重児の消化管穿孔14例に関する検討2009

    • Author(s)
      永田公二, 江角元史郎, 手柴理沙, 木下義晶, 増本幸二, 高畑靖, 原寿郎, 田口智章
    • Journal Title

      日本周産期新生児学会雑誌 45巻

      Pages: 1104-1107

    • NAID

      10029090800

    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Journal Article] Outcome and treatment in an antenatally diagnosed congenital cystic a denomatoid malformation of the lung2009

    • Author(s)
      Kouji Nagata, Kouji Masumoto, Risa Tesiba, Genshirou Esumi, Kiyomi Tsukimori, Norio Wake, Tomoaki Taguchi
    • Journal Title

      Pediatric Surgery International 25巻

      Pages: 753-757

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 新生児腸間膜裂孔ヘルニアの1例2009

    • Author(s)
      永田公二、増本幸二、田尻達郎、田口智章
    • Journal Title

      日本小児外科学会雑誌 45巻

      Pages: 1055-1059

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cx43 play important roles in the lung development2009

    • Author(s)
      Kouii Nagata, Kouji Masumoto, Risa Tesiba, Genshirou Esumi, Keigo Yoshizaki, Satoshi Fukumoto, Kazuaki Nonaka, Tomoaki Taguchi
    • Journal Title

      Journal of Pediatric Surgery 44巻

      Pages: 2296-2301

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] メッケル憩室を伴った新生児腸管部分拡張症の1例2008

    • Author(s)
      上杉達, 田尻達郎, 永田公二, 家入里志, 増本幸二, 田口智章
    • Journal Title

      小児外科 40巻

      Pages: 721-724

    • Related Report
      2010 Final Research Report
  • [Journal Article] 横隔膜ヘルニアの治療ストラテジー低出生体重児に合併した先天性横隔膜ヘルニアの治療成績2008

    • Author(s)
      増本幸二, 手柴理沙, 江角元史郎, 永田公二, 高畑靖, 原寿郎, 月森清己, 和氣徳夫, 田口智章
    • Journal Title

      日本周産期・新生児医学会雑誌 44巻

      Pages: 1064-1068

    • Related Report
      2010 Final Research Report
  • [Journal Article] Risk of respiratory syncytial virus in survivors with severe congenital diaphragmatic hernia.2008

    • Author(s)
      Masumoto K, Nagata K, Uesugi T, Yamada T, Kinjo T, Hikino S, Hara T, Taguchi T.
    • Journal Title

      Pediatr Int. 50

      Pages: 459-463

    • NAID

      10025344254

    • Related Report
      2010 Final Research Report
  • [Journal Article] Chronological change in intramural components in severe proximally dilated jejunal atresia : an immunohistochemical study.2008

    • Author(s)
      Masumoto K, Akiyoshi J, Nagata K, Uesugi T, Taguchi S, Tajiri T, Taguchi T.
    • Journal Title

      J Pediatr Gastroenterol Nutr. 46

      Pages: 602-606

    • Related Report
      2010 Final Research Report
  • [Journal Article] メッケル憩室を伴った新生児腸管部分拡張症の1例2008

    • Author(s)
      上杉達, 田尻達郎, 永田公二, 家入里志, 増本幸二, 田口智章
    • Journal Title

      小児外科 40

      Pages: 721-724

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 横隔膜ヘルニアの治療ストラテジー低出生体重児に合併した先天性横隔膜ヘルニアの治療成績2008

    • Author(s)
      増本幸二, 手柴理沙, 江角元史郎, 永田公二, 高畑靖, 原寿郎, 月森清己, 和氣徳夫, 田口智章
    • Journal Title

      日本周産期・新生児医学会雑誌 44

      Pages: 1064-1068

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Risk of respiratory syncytial virus in survivors with severe congenital diaphragmatic hernia2008

    • Author(s)
      Masumoto K, Naqata K, Uesugi T, Yamada T, Kinjo T, Hikino S, H ara T, Taguchi T
    • Journal Title

      Pediatr Int 50

      Pages: 459-463

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chronological change in intramural components in severe proximally dilated jejunal atresia : an immunohistochemical study2008

    • Author(s)
      Masumoto K, Akiyoshi J, Naciata K, Uesugi T, Taguchi S, Tajiri T, Taguchi T
    • Journal Title

      J Pediatr Gastroenterol Nutr 46

      Pages: 602-606

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Review of 17 cases of extremely low birth weight infants associated with intestinal perforation.2011

    • Author(s)
      Nagata K, Teshiba R, Masumoto K, Esumi G, Kinoshita Y, Tomoaki Taguchi.
    • Organizer
      23rd International Symposium on Pediatric Surgical Research.
    • Place of Presentation
      東京
    • Year and Date
      2011-09-14
    • Related Report
      2010 Final Research Report
  • [Presentation] 当科で経験したlong gap食道閉鎖症の長期経過に対する検討2011

    • Author(s)
      永田公二、江角元史郎、手柴理沙、木下義晶、増本幸二、田口智章
    • Organizer
      第46回周産期新生児学会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-07-13
    • Related Report
      2010 Final Research Report
  • [Presentation] Hypoganglionosis長期経過観察中に低P血症、低Mg血症を発症した1成人例2011

    • Author(s)
      永田公二、江角元史郎、手柴理沙、増本幸二、田口智章
    • Organizer
      第47回日本外科代謝栄養学会
    • Place of Presentation
      横浜
    • Year and Date
      2011-07-09
    • Related Report
      2010 Final Research Report
  • [Presentation] 両側横隔膜ヘルニアの1例2011

    • Author(s)
      永田公二、江角元史郎、手柴理沙、木下義晶、増本幸二、田口智章
    • Organizer
      第47回日本小児外科学会
    • Year and Date
      2011-06-11
    • Related Report
      2010 Final Research Report
  • [Presentation] Axillary crease incision for pediatric thoracotomy.2010

    • Author(s)
      Nagata K, Teshiba R, Masumoto K, Esumi G, Kinoshita Y, Tomoaki Taguchi.
    • Organizer
      3rd World Congress of Pediatric Surgery.
    • Place of Presentation
      New Delhi, India
    • Year and Date
      2010-10-22
    • Related Report
      2010 Final Research Report
  • [Presentation] Axillary crease incision for pediatric thoracotomy2010

    • Author(s)
      Nagata Kouji, 他
    • Organizer
      3^<rd> World Congress of Pediatric Surgery
    • Place of Presentation
      Taji Palace Hotel(インド)
    • Year and Date
      2010-10-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] Review of 17 cases of extremely low birth weight infants associated with intestinal perforation2010

    • Author(s)
      Nagata Kouji, 他
    • Organizer
      23rd International Symposium on Pediatric Surgical Research
    • Place of Presentation
      都市センターホテル(東京都)
    • Year and Date
      2010-09-14
    • Related Report
      2010 Annual Research Report
  • [Presentation] 当科で経験したlong gap食道閉鎖症の長期経過に対する検討2010

    • Author(s)
      永田公二, 他
    • Organizer
      第46回日本周産期・新生児医学会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Year and Date
      2010-07-13
    • Related Report
      2010 Annual Research Report
  • [Presentation] Hypoganglionosis長期経過観察中に低P血症、低Mg血症を発症した1成人例2010

    • Author(s)
      永田公二, 他
    • Organizer
      第47回日本外科代謝栄養学会
    • Place of Presentation
      神奈川県民ホール(神奈川県)
    • Year and Date
      2010-07-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] 両側横隔膜ヘルニアの1例2010

    • Author(s)
      永田公二, 他
    • Organizer
      第47回日本小児外科学会
    • Place of Presentation
      愛知県産業労働センター ウインク愛知(愛知県)
    • Year and Date
      2010-06-11
    • Related Report
      2010 Annual Research Report
  • [Presentation] 難治性手術創に対する陰圧閉鎖療法の適応2010

    • Author(s)
      永田公二、江角元史郎、手柴理沙、木下義晶、増本幸二、田口智章、他
    • Organizer
      第24回小児ストーマ・排泄管理研究会
    • Place of Presentation
      埼玉
    • Year and Date
      2010-04-24
    • Related Report
      2010 Final Research Report
  • [Presentation] 難治性手術創に対する陰圧閉鎖療法の適応2010

    • Author(s)
      永田公二, 他
    • Organizer
      第24回小児ストーマ・排泄管理研究会
    • Place of Presentation
      埼玉会館(埼玉県)
    • Year and Date
      2010-04-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] 当科における横隔膜ヘルニアの治療戦略2010

    • Author(s)
      永田公二、江角元史郎、手柴理沙、木下義晶、増本幸二、田口智章、他
    • Organizer
      第110回日本外科学会定期学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2010-04-09
    • Related Report
      2010 Final Research Report
  • [Presentation] 当科における横隔膜ヘルニアの治療戦略2010

    • Author(s)
      永田公二, 他
    • Organizer
      第110回日本外科学会定期学術集会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Year and Date
      2010-04-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] 小児嚢胞性肺疾患に対する腋窩皺切開の検討2009

    • Author(s)
      永田公二, 江角元史郎, 手柴理沙, 木下義晶, 田口智章
    • Organizer
      第20回小児呼吸器外科研究会
    • Place of Presentation
      高崎
    • Year and Date
      2009-10-17
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] 胸骨翻転術を施行した漏斗胸愚者の長期成績に関する検討2009

    • Author(s)
      永田公二, 江角元史郎, 手柴理沙, 木下義晶, 田口智章
    • Organizer
      第39回九州小児外科研究会
    • Place of Presentation
      沖縄
    • Year and Date
      2009-08-22
    • Related Report
      2009 Annual Research Report
  • [Presentation] 胸骨翻転術を施行した漏斗胸患者の長期成績に関する検討2009

    • Author(s)
      永田公二, 江角元史郎, 手柴理沙, 木下義晶, 田口智章
    • Organizer
      第39回九州小児外科研究会
    • Place of Presentation
      沖縄
    • Year and Date
      2009-08-02
    • Related Report
      2010 Final Research Report
  • [Presentation] 当科にて経験した超低出生体重児の消化管穿孔14例に関する検討2009

    • Author(s)
      永田公二, 江角元史郎, 手柴理沙, 木下義晶, 増本幸二, 高畑靖, 原寿郎, 田口智章
    • Organizer
      第44回日本周産期新生児学会
    • Place of Presentation
      名古屋
    • Year and Date
      2009-07-13
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] Cx43 plays important roles in lung development.2009

    • Author(s)
      Kouji Nagata, Genshirou Esumi, Risa Teshiba, Kouji Masumoto, Keigo Yoshizaki, Satoshi Fukumoto, Kazuaki Nonaka, Tomoaki Taguchi.
    • Organizer
      42nd Annual Meeting of Pacific Association of Pediatric Surgeons.
    • Place of Presentation
      Hong Kong
    • Year and Date
      2009-05-11
    • Related Report
      2010 Final Research Report
  • [Presentation] Cx43 plays important roles in lung development.2009

    • Author(s)
      Kouji Nagata, Genshirou Esumi, Risa Teshiba, Kouji Masumoto, Keigo Yoshizaki, Satoshi Fukumoto, Kazuaki Nonaka, Tomoaki Taguchi
    • Organizer
      42nd Annual Meeting of Pacific Association of Pediatric Surgeons
    • Place of Presentation
      Hong Kong
    • Year and Date
      2009-05-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] 虫垂切除術時に偶発的に発見された回腸異所性胃粘膜の1例2008

    • Author(s)
      永田公二, 藤花菜, 増本幸二, 田口智章
    • Organizer
      第452回小児科学会福岡地方会
    • Place of Presentation
      福岡
    • Year and Date
      2008-12-13
    • Related Report
      2010 Final Research Report 2008 Annual Research Report
  • [Presentation] The postnatal outcome and timing of surgery for an antenatally diagnosed CCAM of the lung.2008

    • Author(s)
      Kouji Nagata, Risa Tesiba, Genshirou Esumi, Kouji Masumoto, Tomoaki Taguchi.
    • Organizer
      21th Congress of Asian Association of Pediatric Surgeons.
    • Place of Presentation
      Bankok, Thai
    • Year and Date
      2008-11-17
    • Related Report
      2010 Final Research Report
  • [Presentation] The postnatal outcome and timing of surgery for an antenatally diagnosed congenital cystic adenomatoid malformation of the lung2008

    • Author(s)
      Kouji Nagata, Risa Tesiba, Gens hirouEsumi, Kouji Masumoto and Tomoaki Taguchi
    • Organizer
      21th Congress of Asian Association of Pediatric Surgeons
    • Place of Presentation
      Bankok, Thai
    • Year and Date
      2008-11-17
    • Related Report
      2008 Annual Research Report
  • [Presentation] 当科にて経験した超低出生体重児の消化管穿孔13例に関する検討2008

    • Author(s)
      永田公二, 江角元史郎, 手柴理沙, 増本幸二, 田口智章
    • Organizer
      第28回日本小児内視鏡外科手術手技研究会
    • Place of Presentation
      大阪
    • Year and Date
      2008-11-09
    • Related Report
      2010 Final Research Report 2008 Annual Research Report
  • [Presentation] 出生前診断された先天性嚢胞性腺腫様奇形(CCAM)症例に関する検討2008

    • Author(s)
      永田公二, 江角元史郎, 手柴理沙, 増本幸二, 田口智章
    • Organizer
      第44回日本周産期新生児学会
    • Place of Presentation
      横浜
    • Year and Date
      2008-07-14
    • Related Report
      2010 Final Research Report 2008 Annual Research Report
  • [Presentation] 当科における出生前診断された先天性嚢胞性腺腫様奇形(CCAM)症例に関する検討2008

    • Author(s)
      永田公二, 江角元史郎, 手柴理沙, 増本幸二,田口智章
    • Organizer
      第45回日本小児外科学会学術集会
    • Place of Presentation
      筑波
    • Year and Date
      2008-05-28
    • Related Report
      2010 Final Research Report 2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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