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Development of the treatment for intractable skin ulcer using monolayered mesenchymal cell sheets

Research Project

Project/Area Number 20791308
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Plastic surgery
Research InstitutionTottori University

Principal Investigator

SUYAMA Yoshiko  Tottori University, 医学部附属病院, 助教 (90448192)

Research Collaborator NAKAYAMA Bin  鳥取大学, 医学部附属病院, 准教授 (50271565)
KITANO Hiroya  鳥取大学, 医学部附属病院, 教授 (20153108)
YAMAMOTO Yasutaka  鳥取大学, 大学院・医学系研究科, 助教 (20362882)
HISATOME Ichiro  鳥取大学, 大学院・医学系研究科, 教授 (60211504)
Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords再生医学 / 間葉系細胞 / 細胞培養シート / 難治性皮膚潰瘍
Research Abstract

Intractable skin ulcers are often caused by ischemia, and in the practice, most patients are elderly people. Therefore, we made monolayered mesenchymal cell sheets with the ability of angiogenesis, derived from subcutaneous adipose tissue of young and aged rats. And young rats with wounds were divided two groups, grafted young cell sheet(group Y)and grafted aged one(group A). We evaluated the effect of treatment as wound area and wound blood flow. Group A was inferior to group Y, but was better than wounds without cell sheet grafting. This finding suggests that it is possible to use cells derived from elderly people as treatment, but the improvement is necessary to reach young cells.

Report

(3 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • Research Products

    (3 results)

All 2010 2009

All Presentation (2 results) Book (1 results)

  • [Presentation] 皮下脂肪組織由来間葉系細胞培養シートを用いた難治性潰瘍治療法の開発2010

    • Author(s)
      陶山淑子
    • Organizer
      第6回山陰形成外科懇話会(発表確定)
    • Place of Presentation
      松江市立病院(松江市)
    • Year and Date
      2010-05-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] 皮下脂肪組織由来間葉系細胞培養シートを用いた難治性潰瘍治療法の開発2010

    • Author(s)
      陶山淑子
    • Organizer
      第6回山陰形成外科懇話会
    • Place of Presentation
      松江市立病院(松江市)(発表確定)
    • Related Report
      2009 Final Research Report
  • [Book] ケロイド・肥厚性瘢痕研究会2009

    • Author(s)
      陶山淑子
    • Publisher
      株式会社メディカルトリビューン
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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