What has happened in the preliminary AV shunt loop?-Experiments in rabbits.
| Project/Area Number |
20791309
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Plastic surgery
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| Research Institution | Kagawa University |
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Principal Investigator |
KOGURE Tetsukuni Kagawa University, 医学部附属病院, 助教 (40437695)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2008: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | AV shunt loop / 乱流 / 血栓 / 外科 / 生体機能利用 / 循環器・高血圧 / 細胞・組織 / 生体物理 / AV shunt loopモデル / マイクロサージャリー / ウサギ / 血流量 / 血液粘度 / 血管吻合 |
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| Research Abstract |
The preliminary AV shunt loop is known as the simplified method of vein graft, and has been widely performed in the microsurgical reconstruction. However, this method involves the risk of thrombosis due to turbulence. In the present study, an experimental model of the preliminary AV shunt model was created to investigate what has happened in the AV shunt loop. The result showed that turbulent flow is likely to occur in the AV shunt loop and the shear stress over 200 dyne/cm^2 act on the outer side of the loop vessel. Conclusion : Endothelium damage under a high shear stress and turbulent flow were thought to cause a high incidence of thrombosis and obstruction in the most distal part of AV shunt loop.
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Report
(4 results)
Research Products
(2 results)
