Relationship between prolonged ischemia and rejection in composite tissue allotransplantation

Research Project

Project/Area Number	20791311
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Plastic surgery
Research Institution	Oita University
Principal Investigator	SHIMIZU Fumiaki Oita University, 医学部, 助教 (50347027)
Project Period (FY)	2008 – 2009
Project Status	Completed (Fiscal Year 2009)
Budget Amount *help	¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000) Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000) Fiscal Year 2008: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Keywords	組織培養 / 移植学 / 虚血時間 / 虚血再潅流障害 / 同種異系間複合組織移植 / ischemic preconditioning / ステロイド局所投与
Research Abstract	Relationship between ischemia time and rejection of transplanted allograft was assessed using Rat composite tissue allo-transplantation model. As the result, clinical observation, histopathological examination and mixed lymphocyte reaction assay revealed that prolonged ischemia increases severity of rejection in skin flap allotransplantation. Higher expression of MHC-II antigen in longer ischemia group might cause these results.

Report

(3 results)