Relationship between prolonged ischemia and rejection in composite tissue allotransplantation
Project/Area Number |
20791311
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
Plastic surgery
|
Research Institution | Oita University |
Principal Investigator |
SHIMIZU Fumiaki Oita University, 医学部, 助教 (50347027)
|
Project Period (FY) |
2008 – 2009
|
Project Status |
Completed (Fiscal Year 2009)
|
Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2008: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
|
Keywords | 組織培養 / 移植学 / 虚血時間 / 虚血再潅流障害 / 同種異系間複合組織移植 / ischemic preconditioning / ステロイド局所投与 |
Research Abstract |
Relationship between ischemia time and rejection of transplanted allograft was assessed using Rat composite tissue allo-transplantation model. As the result, clinical observation, histopathological examination and mixed lymphocyte reaction assay revealed that prolonged ischemia increases severity of rejection in skin flap allotransplantation. Higher expression of MHC-II antigen in longer ischemia group might cause these results.
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Report
(3 results)
Research Products
(3 results)