Decreased death receptor pathway of apoptotic signaling in septic mouse gut : effect of nutrition support

• Project/Area Number: 20791324
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Emergency medicine
• Research Institution: Kyoto University
• Principal Investigator: FUTATSUGI Motonori Kyoto University, 医学研究科, 助教 (70419589)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2008: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: 敗血症 / 経腸栄養 / Death受容体 / アポトーシス / 消化管

Research Abstract

In this study, we found that the expression of TNF-R1, Fas, and cleaved caspase-3 was elevated in duodenum or jejunum or ileum in digestive tract of CLP-induced septic mice. In ileum of CLP-induced septic mice with EN, and the expression of death receptors (TNF-R1, Fas) and cleaved caspase-3 was down-regulated.

Research Products

• [Presentation] 敗血症病態の消化管におけるEPA/GLA配合経腸栄養剤のアポトーシス抑制作用 (2010)
  • Author(s): 二木元典
  • Organizer: 第110回日本外科学会総会
  • Place of Presentation: 名古屋市
  • Year and Date: 2010-04-09
• [Presentation] 敗血症病態の消化管におけるEPA/GLA配合経腸栄養剤のcaspase 3発現の抑制効果 (2009)
  • Author(s): 二木元典
  • Organizer: 第37回日本救急医学会総会
  • Place of Presentation: 盛岡市
  • Year and Date: 2009-10-29
• [Presentation] 敗血症病態の消化管におけるEPA/GLA配合経腸栄養剤のcaspase 3発現の抑制効果 (2009)
  • Author(s): 二木元典
  • Organizer: 第37回日本救急医学会総会
  • Place of Presentation: 盛岡市民文化ホール
  • Year and Date: 2009-10-29
• [Presentation] 敗血症病態の胃腸管におけるEPA/GLA配合経腸栄養剤のアポトーシス抑制作用 (2009)
  • Author(s): 二木元典
  • Organizer: 第109回日本外科学会総会
  • Place of Presentation: 福岡市
  • Year and Date: 2009-04-02
• [Presentation] 敗血症病態の胃腸管におけるEPA/GLA配合経腸栄養剤のアポトーシス抑制作用 (2009)
  • Author(s): 二木元典
  • Organizer: 第109回日本外科学会定期学術集会
  • Place of Presentation: マリンメッセ福岡
  • Year and Date: 2009-04-02