The effect of nicaraven to organ dysfunctions in sepsis

• Project/Area Number: 20791326
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Emergency medicine
• Research Institution: Keio University
• Principal Investigator: SUZUKI Takeshi Keio University, 医学部, 助教 (80327600)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 敗血症 / 臓器障害 / 活性酸素種 / ニカラベン / 臓器保護 / 心筋保護

Research Abstract

I examined the effects of nicaraven to sepsis, using a rat cecal ligation and perforation model. At first, I evaluated whether a nicaraven infusion has beneficial effects to mortality and cardiac dysfunction or not. In the evaluation of cardiac function, I measured cardiac output, cardiac work and cardiac efficiency using a working heart model. Although there are only a few datas, a nicaraven therapy has little beneficial effects to mortality and cardac dysfunction at this time.