Study of bone and cementum formation through phosphate/pyrophosphate balance

Research Project

Project/Area Number	20791335
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Morphological basic dentistry
Research Institution	Osaka University
Principal Investigator	SATO Sunao Osaka University, 大学院・歯学研究科, 講師 (70335660)
Project Period (FY)	2008 – 2009
Project Status	Completed (Fiscal Year 2009)
Budget Amount *help	¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000) Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000) Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords	硬組織 / リン酸 / ピロリン酸 / 骨 / セメント質 / ヒロリン酸 / セメント芽細胞 / 骨芽細胞
Research Abstract	We revealed that phosphate/pyrophosphate imbalance inhibit the proliferation of cementoblast and osteoblast cell line but enhanced the differentiation of cementoblast and osteoblast cell line with the experiment of additional phosphate mimicking phosphate/pyrophosphate imbalance. Moreover, we revealed that phosphate/pyrophosphate imbalance changes some of the same gene in cementoblast and osteoblast cell line, but some other genes were different between cementoblast cell line and osteoblast cell line.

Report

(3 results)