Study of bone and cementum formation through phosphate/pyrophosphate balance
| Project/Area Number |
20791335
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
SATO Sunao Osaka University, 大学院・歯学研究科, 講師 (70335660)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 硬組織 / リン酸 / ピロリン酸 / 骨 / セメント質 / ヒロリン酸 / セメント芽細胞 / 骨芽細胞 |
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| Research Abstract |
We revealed that phosphate/pyrophosphate imbalance inhibit the proliferation of cementoblast and osteoblast cell line but enhanced the differentiation of cementoblast and osteoblast cell line with the experiment of additional phosphate mimicking phosphate/pyrophosphate imbalance. Moreover, we revealed that phosphate/pyrophosphate imbalance changes some of the same gene in cementoblast and osteoblast cell line, but some other genes were different between cementoblast cell line and osteoblast cell line.
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Report
(3 results)
Research Products
(4 results)
