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Study of bone and cementum formation through phosphate/pyrophosphate balance

Research Project

Project/Area Number 20791335
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Morphological basic dentistry
Research InstitutionOsaka University

Principal Investigator

SATO Sunao  Osaka University, 大学院・歯学研究科, 講師 (70335660)

Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords硬組織 / リン酸 / ピロリン酸 / 骨 / セメント質 / ヒロリン酸 / セメント芽細胞 / 骨芽細胞
Research Abstract

We revealed that phosphate/pyrophosphate imbalance inhibit the proliferation of cementoblast and osteoblast cell line but enhanced the differentiation of cementoblast and osteoblast cell line with the experiment of additional phosphate mimicking phosphate/pyrophosphate imbalance. Moreover, we revealed that phosphate/pyrophosphate imbalance changes some of the same gene in cementoblast and osteoblast cell line, but some other genes were different between cementoblast cell line and osteoblast cell line.

Report

(3 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • Research Products

    (4 results)

All 2009 2008

All Presentation (4 results)

  • [Presentation] リン酸による歯周組織を構成する細胞への影響2009

    • Author(s)
      山元有里
    • Organizer
      日本骨代謝学会学術集会
    • Place of Presentation
      大阪国際会議場(大阪)
    • Year and Date
      2009-07-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] リン酸による歯周組織を構成する細胞への影響2009

    • Author(s)
      山元有里・佐藤淳・香川良介・豊澤悟
    • Organizer
      第27回日本骨代謝学会学術集会
    • Related Report
      2009 Final Research Report
  • [Presentation] リン酸による歯小嚢細胞の石灰化関連遺伝子発現について2008

    • Author(s)
      山元有理
    • Organizer
      第19回日本臨床口腔病理学会総会・学術大会
    • Place of Presentation
      東京・東京歯科大学水道橋校舎
    • Year and Date
      2008-08-22
    • Related Report
      2008 Annual Research Report
  • [Presentation] リン酸による歯小嚢細胞の石灰化関連遺伝子発現について2008

    • Author(s)
      山元有里・佐藤淳・岸野万伸・小川裕三・豊澤悟
    • Organizer
      第19回日本臨床口腔病理学会学術大会
    • Related Report
      2009 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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