Identification of a novel tumor suppressor gene at 1p36 chromosomal region in oral squamous cell carcinomas.
| Project/Area Number |
20791337
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Morphological basic dentistry
|
|---|
| Research Institution | Okayama University |
|---|
Principal Investigator |
TAMAMURA Ryo Okayama University, 大学院・医歯薬学総合研究科, 助教 (00403494)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Keywords | 癌抑制遺伝子 / 扁平上皮癌 / 口腔癌 / LOH解析 / LOH解折 / 発癌 |
|---|
| Research Abstract |
To investigate the presence of tumor suppressor gene (TSG) at 1p36 chromosomal region, I have analyzed loss of heterozygosity (LOH) in oral squamous cell carcinoma (OSCC). As a result of this study three frequently deleted regions that harbor some potential TSG involved in OSCC carcinogenesis were identified. I focused on RIZ gene which existed in the most highest deletion region, and have done genetic analysis. Two polymorphisms of RIZ gene have been found in OSCC.
|
Report
(4 results)
Research Products
(31 results)
-
-
-
-
-
-
-
-
-
-
-
-
[Journal Article] Deletion at Dickkopf (dkk)-3 locus (11p15.2) is related with lower lymph node metastasis and better prognosis in head and neck squamous cell carcinomas.2008
Author(s)
Katase N, Gunduz M, Beder L, Gunduz E, Lefeuvre M, Hatipoglu OF, Borkosky SS, Tamamura R, Tominaga S, Yamanaka N,Shimizu K, Nagai N, Nagatsuka H.
-
Journal Title
Oncol Res. 17(6)
Pages: 273-82
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] 上顎歯肉腫瘍2008
Author(s)
片瀬直樹
Organizer
第19回日本臨床口腔病理学会
Place of Presentation
東京
Year and Date
2008-08-21
Related Report
