Aurora-A ; Phosphoregulation and its abnormality in Oral Cancer

Research Project

Project/Area Number	20791338
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Morphological basic dentistry
Research Institution	Hiroshima University
Principal Investigator	KITAJIMA Shojiro Hiroshima University, 大学院・医歯薬学総合研究科, 助教 (00452590)
Project Period (FY)	2008 – 2009
Project Status	Completed (Fiscal Year 2009)
Budget Amount *help	¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000) Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000) Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords	Aurora-A / PP2A / 口腔癌 / リン酸化 / 細胞周期 / 細胞分裂 / ユビキチン / 脱リン酸化
Research Abstract	The purpose of this project is to reveal the mechanism of Aurora-A degradation mediated by phosphorylation and the mechanism that causes Aurora-A overexpression. We examined the binding of Aurora-A to PP2A complex and the activity of PP2A in oral cancer cell lines. We further approached the regulation of PP2A mediated by regulatory B subunit and its biological meanings.