| Project/Area Number |
20791343
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Tokyo Dental College |
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Principal Investigator |
SASAKI Hodaka Tokyo Dental College, 歯学部, 助教 (50433959)
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| Project Period (FY) |
2008 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 歯学 / 発生・分化 / 歯牙発生 / マイクロアレイ / 歯乳頭 / 歯髄 |
|---|
| Research Abstract |
It was known that important factors involved in odontogenesis in mouse dental papillae disappear between the pre- and post-natal stages of development. We examined unknown genes had down-regulated expression after birth by genome microarray analysis. The number of up-regulated genes showing an over 2-fold change decreased with time. On the other hand, the number of down-regulated genes was highest between pre- and post-natal (3,130 genes). Those were included 1,038 unknown genes, and it was recognized 16 genes, had significant reduction (fold value >10). These result suggest those down-regulated unknown genes were important factors in normal odontogenesis in dental papillae.
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