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Influence of histon deacetyrase inhibitor in induction of tumor-associated stroma in oral cancer cell line.

Research Project

Project/Area Number 20791344
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Morphological basic dentistry
Research InstitutionNihon University

Principal Investigator

MATSUMOTO Naoyuki  Nihon University, 歯学部, 助教 (20386080)

Co-Investigator(Renkei-kenkyūsha) 小宮山 一雄  日本大学, 歯学部, 教授 (00120452)
我孫子 宜光  日本大学, 松戸歯学部, 教授 (70050086)
Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords癌 / リンパ管新生 / 血管新生 / 腫瘍問質誘導 / DNA転写調節 / 転移 / 腫瘍間質誘導
Research Abstract

We investigated the effect of sodium butyrate (SB), one of histone deacetylase inhibitor on oral cancer cells. RNA and protein expression level of angiogenic- and lymphangiogenic-factors are assessed. Expression level of angiopoietin-2, platelet derived growth factor beta, VEGF-C, VEGF-D are downregulated by SB stimulation. These findings indicating its potential use in anti-angiogenic and -lymphangiogenic cancer therapy. Interestingly, agiogenic factor VEGF-A and transcription regulator COX-2 are upregulated. Now, we investigated detail of the mechanism.

Report

(3 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • Research Products

    (1 results)

All 2008

All Presentation (1 results)

  • [Presentation] COX-2 high expression in the oral squamous epithelium relate to keratinocyte dif ferentiation but not for cell nroliferation2008

    • Author(s)
      Komiyama K, Matsumoto N, et.al.
    • Organizer
      14^<th> International Congress, International Association of Oral Pathologists
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2008-07-23
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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