An analysis of odontoblast differentiation mechanisms by using dental pulp SP cells
| Project/Area Number |
20791347
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Matsumoto Dental University |
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Principal Investigator |
HOSOYA Akihiro Matsumoto Dental University, 歯学部, 講師 (70350824)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 歯髄 / 象牙芽細胞 / 分化 / 分化因子 / SP細胞 / 再生医学 |
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| Research Abstract |
Although a number of studies suggest that many transcription factors participate in odontoblast differentiation, specific factors of odontoblast differentiation are still unknown. In the present study, immunohistochemical localizations for SUMO proteins and Osterix were visible in the immature odontoblasts ; however these immunoreactivities were reduced in the mature odontoblasts. These results demonstrate that reduction of expressions for SUMO proteins and Osterix in the mature odontoblasts might be necessary for dentin formation.
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Report
(3 results)
Research Products
(17 results)
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[Journal Article] Alveolar bone regeneration of subcutaneously transplanted rat molar.2008
Author(s)
Akihiro Hosoya, Tadashi Ninomiya, Toru Hiraga, Chen Zhao, Kunihiko Yoshiba, Nagako Yoshiba, Takahiro Okabe, Shigeyuki Wakitani, Hirohito Yamada, Etsuo Kasahara, Hidehiro Ozawa, Hiroaki Nakamura
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Journal Title
Bone 42(2)
Pages: 350-357
Related Report
Peer Reviewed
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