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An analysis of odontoblast differentiation mechanisms by using dental pulp SP cells

Research Project

Project/Area Number 20791347
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Morphological basic dentistry
Research InstitutionMatsumoto Dental University

Principal Investigator

HOSOYA Akihiro  Matsumoto Dental University, 歯学部, 講師 (70350824)

Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords歯髄 / 象牙芽細胞 / 分化 / 分化因子 / SP細胞 / 再生医学
Research Abstract

Although a number of studies suggest that many transcription factors participate in odontoblast differentiation, specific factors of odontoblast differentiation are still unknown. In the present study, immunohistochemical localizations for SUMO proteins and Osterix were visible in the immature odontoblasts ; however these immunoreactivities were reduced in the mature odontoblasts. These results demonstrate that reduction of expressions for SUMO proteins and Osterix in the mature odontoblasts might be necessary for dentin formation.

Report

(3 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • Research Products

    (17 results)

All 2010 2009 2008

All Journal Article (13 results) (of which Peer Reviewed: 10 results) Presentation (4 results)

  • [Journal Article] Potential of periodontal ligament cells to regenerate alveolar bone.2010

    • Author(s)
      Akihiro Hosoya, Tadashi Ninomiya, Toru Hiraga, Kunihiko Yoshiba, Nagako Yoshiba, Etsuo Kasahara, Hidehiro Ozawa, Hiroaki Nakamura
    • Journal Title

      J Oral Biosci 52(2)

      Pages: 72-80

    • NAID

      10027105411

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Potential of Periodontal Ligament Cells to Regenerate Alveolar Bone2010

    • Author(s)
      Hosoya A.et al.
    • Journal Title

      Journal of Oral Biosciences 52(In press)

    • NAID

      10027105411

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of p63 during early craniofacial development of the mouse embryo.2009

    • Author(s)
      Akihiro Hosoya, Jong-Min Lee, Ji-Youn Kim, Han-Sung Jung, Sung-Won Cho
    • Journal Title

      Dev Reprod 13(2)

      Pages: 89-95

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 歯髄を用いた再生療法の試み2009

    • Author(s)
      細矢明宏
    • Journal Title

      歯界展望 113(6)

      Pages: 1174-1175

    • Related Report
      2009 Final Research Report
  • [Journal Article] 歯根膜幹細胞を用いた歯周組織再生2009

    • Author(s)
      細矢明宏
    • Journal Title

      The BONE 23(1)

      Pages: 108-109

    • Related Report
      2009 Final Research Report
  • [Journal Article] Expression of p63 during early craniofacial development of the mouse embryo2009

    • Author(s)
      Hosoya A.et al.
    • Journal Title

      Development and Reproduction 13

      Pages: 89-95

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Morphological evidence of basal keratinocyte migration during the re-epithelialization process.2008

    • Author(s)
      Akihiro Hosoya, Jong-Min Lee, Sung-Won Cho, Ji-Youn Kim, Naoshi Shinozaki, Takahiko Shibahara, Masaki Shimono, Han-Sung Jung
    • Journal Title

      Histochem Cell Biol 130(6)

      Pages: 1165-1175

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Alveolar bone regeneration of subcutaneously transplanted rat molar.2008

    • Author(s)
      Akihiro Hosoya, Tadashi Ninomiya, Toru Hiraga, Chen Zhao, Kunihiko Yoshiba, Nagako Yoshiba, Takahiro Okabe, Shigeyuki Wakitani, Hirohito Yamada, Etsuo Kasahara, Hidehiro Ozawa, Hiroaki Nakamura
    • Journal Title

      Bone 42(2)

      Pages: 350-357

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] BMP4 signaling regulates formation of Hertwig's epithelial root sheath during tooth root development.2008

    • Author(s)
      Akihiro Hosoya, Ji-Youn Kim, Sung-Won Cho, Han-Sung Jung
    • Journal Title

      Cell Tissue Res 333(3)

      Pages: 503-509

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 歯根膜組織の歯槽骨再生能2008

    • Author(s)
      細矢明宏、二宮禎、平賀徹、Zhao Chen、吉羽邦彦、吉羽永子、高橋将文、岡部高弘、脇谷滋之、山田博仁、笠原悦男、小澤英浩、中村浩彰
    • Journal Title

      The BONE 22(1)

      Pages: 3-7

    • Related Report
      2009 Final Research Report
  • [Journal Article] Alveolar bone regeneration of subcutaneously transplanted rat molar2008

    • Author(s)
      Hosoya A., et.al.
    • Journal Title

      Bone 42

      Pages: 350-357

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] BMP4 signaling regulates formation of Hertwig's epithelial root sheath during tooth root development2008

    • Author(s)
      Hosoya A., et.al.
    • Journal Title

      Cell and Tissue Research 333

      Pages: 503-509

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Morphological evidence of basal keratinocyte migration during the re-epithelialization process2008

    • Author(s)
      Hosoya A., et.al.
    • Journal Title

      Histochemistry and Cell Biology 130

      Pages: 1165-1175

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] 歯根膜組織の歯槽骨再生能2009

    • Author(s)
      細矢明宏
    • Organizer
      第51回歯科基礎医学会学術大会
    • Place of Presentation
      新潟(J Oral Biosci (Supplement)
    • Year and Date
      2009-09-11
    • Related Report
      2009 Final Research Report
  • [Presentation] 歯根膜組織の歯槽骨再生能2009

    • Author(s)
      細矢明宏
    • Organizer
      第51回歯科基礎医学会学術大会
    • Place of Presentation
      朱鷺メッセ(新潟市)
    • Year and Date
      2009-09-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] 再植歯の歯髄腔内における骨様組織形成2008

    • Author(s)
      細矢明宏、Zhao Chen、吉羽邦彦、吉羽永子、山田博仁、笠原悦夫、小澤英浩、中村浩彰
    • Organizer
      第128回日本歯科保存学会・春季学会
    • Place of Presentation
      新潟
    • Year and Date
      2008-06-05
    • Related Report
      2009 Final Research Report
  • [Presentation] 再植歯の歯髄腔内における骨様組織形成2008

    • Author(s)
      細矢明宏, 他
    • Organizer
      第128回日本歯科保存学会・春季学会
    • Place of Presentation
      新潟市
    • Year and Date
      2008-06-05
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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