Control of osteoblastic differentiation of periodontal ligament cells via regulation of SUMOylation

Research Project

Project/Area Number	20791348
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Morphological basic dentistry
Research Institution	Matsumoto Dental University
Principal Investigator	YUKITA Akira Matsumoto Dental University, 歯学部, 助教 (80401214)
Project Period (FY)	2008 – 2009
Project Status	Completed (Fiscal Year 2009)
Budget Amount *help	¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000) Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000) Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords	硬組織再生 / SUMO化修飾 / 細胞分化制御 / 骨芽細胞分化 / 再生医療 / BMPシグナル / Wntシグナル
Research Abstract	Establishment of efficient differentiation into osteoblast is one of the most important approaches for regenerative therapy for periodontal disease. Conjugation of SUMO (Small ubiquitin-related modifier) is a post translational modification and regulates various biological events. In this study, I revealed that inhibition of SUMOylation (conjugation of SUMO) enhances osteoblastic differentiation via direct activation of BMP signal.

Report

(3 results)