The activation mechanisms of mechanosensitive cation channels in boneremodeling.
| Project/Area Number |
20791349
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Functional basic dentistry
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| Research Institution | Tohoku University |
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Principal Investigator |
YOSHIDA Takashi Tohoku University, 大学院・歯学研究科, 助教 (30455795)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | 骨芽細胞 / チャネル / RT-PCR法 / 機械的刺激 / カルシウム / real-time PCR法 / MC3T3-E1細胞 / 発現調節 |
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| Research Abstract |
Mechanical stress plays a vital role in maintaining bone architecture. The process by which osteoblasts convert mechanical signal into biochemical responses leading to bone remodeling is not fully understood. In spite of the significant role of channels in osteoblast, the molecular identity of mechanosensitive channels remains unknown. To identify the mechanosensitive channels, we examined the expression level of channels in the clonal mouse osteoblast cell line MC3T3-E1. RT-PCR analysis revealed some mechanosensitive channel genes are expressed in MC3T3-E1 cells.
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Report
(3 results)
Research Products
(13 results)
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[Journal Article] Selective and direct inhibition of TRPC3 channels underlies biological activities of a pyrazole compound.2009
Author(s)
Kiyonaka S, Kato K, Nishida M, Mio K, Numaga T, Sawaguchi Y, Yoshida T, Wakamori M, Mori E, Numata T, Ishii M, Takemoto H, Ojida A, Watanabe K, Uemura A, Kurose H, Morii T, Kobayashi T, Sato Y, Sato C, Hamachi I, Mori Y.
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Journal Title
Proc. Natl. Acad. Sci. U.S.A. 106巻
Pages: 5400-5404
Related Report
Peer Reviewed
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