Study for oral-facial pain control mechanism by periodontal specific cells.

• Project/Area Number: 20791352
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Functional basic dentistry
• Research Institution: Hiroshima University
• Principal Investigator: OKA Hiroko Hiroshima University, 大学院・医歯薬学総合研究科, 特任助教 (60452588)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 炎症 / 組織破壊 / 炎症性疼痛

Research Abstract

In this study, it was indicated that some kinds of component cells in periodontal tissue have receptors for pain and factors known to inhibit pain. The date in this study suggested the possibility that the component cells in periodontal tissue secrete inhibitors for osteoclastogenesis. Moreover, this study suggested that a factor, which is known to differentiate periodontal ligament cells into cementoblasts, has the ability to control inflammation and immunity.