| Project/Area Number |
20791357
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Functional basic dentistry
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| Research Institution | Kyushu Dental College |
|---|
Principal Investigator |
ONO Kentaro Kyushu Dental College, 歯学部, 助教 (40316154)
|
|---|
| Project Period (FY) |
2008 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2008: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
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| Keywords | ニコチン / 唾液腺 / 細胞内カルシウム / 神経 / ニコチン受容体 / 神経終末 / 耳下腺 / 顎下腺 / シチジン |
|---|
| Research Abstract |
Although cigarette smoking induces salivary secretion, it is unclear the induction mechanism. In the present study, we investigated effects of nicotine on rat parotid gland cells using intracellular Ca^<2+> imaging. Nicotine increased intracellular Ca^<2+> concentration in salivary cells, and the response was blocked by drug-induced nerve synaptic blockage. Therefore, it is possible that nicotinic receptors in nerve terminals terminated the salivary gland mediate salivary secretion.
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