The role of p130 Cas in osteoclastic bone resorption
| Project/Area Number |
20791358
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Functional basic dentistry
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| Research Institution | Kyushu Dental College |
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Principal Investigator |
FUKUSHIMA Hidefumi Kyushu Dental College, 歯学部, 助教 (70412624)
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| Co-Investigator(Renkei-kenkyūsha) |
EIJIRO Jimi 九州歯科大学, 歯学部, 教授 (40276598)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 骨 / 破骨細胞 / 骨吸収 / p130 Cas / c-Src / アクチン / Casp130 |
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| Research Abstract |
Integrin-mediated interaction with the extracellular matrix plays a critical role in the function of osteoclasts, the bone-resorbing cells. This study examines the role of p130^<Cas> (Crk-associatedsubstrate (Cas)) in actin organization in osteoclasts.
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Report
(3 results)
Research Products
(31 results)
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[Journal Article] Processing of the NF-Critical for RANKL-Induced Osteoclast Differentiation.
Author(s)
Maruyama T, Fukushima H, Nakao K, Shin M, Yasuda H, Weih F, Doi T, Aoki K, Alles N, Ohya K, Hosokawa R, Jimi E.
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Journal Title
J Bone Miner Res (in press)
Related Report
Peer Reviewed
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