The establishment of molecular mechanisms of circadian rhythm in oral cancer cells
| Project/Area Number |
20791368
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|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Hirosaki University |
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Principal Investigator |
SATO Fuyuki Hirosaki University, 大学院・医学研究科, 助教 (60400131)
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|---|
| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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|---|
| Keywords | 口腔癌 / 概日リズム / DEC / アポトーシス / 癌 / DEC2 / 時計遺伝子 / 分子生物学 / 腫瘍血管新生 |
|---|
| Research Abstract |
It has not been well understood about the significance of the transcription factor DEC expression in oral cancer. We showed that DEC has circadian rhythm in oral cancer cells, and negatively regulates VEGF and cyclinD1 expression. In addition, the protein expression of DEC1 was intensely stained in the tumor regions compared with those in non-tumor regions. These results suggest that DEC1 plays important roles of the tumor development, and would be new molecular target in oral cancer.
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Report
(4 results)
Research Products
(59 results)
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[Book] 虫垂の腫瘍2010
Author(s)
諸橋聡子、佐藤冬樹, など
Total Pages
6
Publisher
先端医学社
Related Report
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