| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Research Abstract |
It has not been well understood about the significance of the transcription factor DEC expression in oral cancer. We showed that DEC has circadian rhythm in oral cancer cells, and negatively regulates VEGF and cyclinD1 expression. In addition, the protein expression of DEC1 was intensely stained in the tumor regions compared with those in non-tumor regions. These results suggest that DEC1 plays important roles of the tumor development, and would be new molecular target in oral cancer.
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