The pathological roles of Th17 cells in Sjogren's syndrome

• Project/Area Number: 20791370
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Pathobiological dentistry/Dental radiology
• Research Institution: Tohoku University
• Principal Investigator: SAKAI Azusa Tohoku University, 病院, 医員 (90463778)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000); Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: シェーグレン症候群 / Th17 / IL-18 / 唾液腺 / IL-17

Research Abstract

The expression of IL-18 was detected in salivary glands of Sjogren's syndrome. Furthermore, the majority of the infiltrating cells were Th17 cells secreting IL-17. IL-18 amplified the secretion of IL-8 induced by low amounts of IL-17 from primary salivary gland cells. The results suggest that IL-18 and Th17 cells are associated with the pathogenesis of Sjogren's syndrome.

Research Products

• [Journal Article] シェーグレン症候群におけるサイトカイン異常 (2009)
  • Author(s): 酒井梓、菅原由美子、黒石智誠、笹野高嗣、菅原俊二
  • Journal Title: リウマチ科 42(2)巻 Pages: 211-216
• [Journal Article] シェーグレン症候群におけるサイトカイン異常 (2009)
  • Author(s): 酒井梓, 菅原由美子, 黒石智誠, 笹野高嗣, 菅原俊二
  • Journal Title: リウマチ科 42(2) Pages: 211-216
• [Journal Article] Identification of IL-18 and Th17 Cells in Salivary Glands of Patients with Sjogren's Syndrome, and Amplification of IL-17-Mediated Secretion of Inflammatory Cytokines from Salivary Gland Cells by IL-18 (2008)
  • Author(s): Sakai A, Sugawara Y, Kuroishi T, Sasano T, Sugawara S
  • Journal Title: Journal of Immunology. 181巻 Pages: 2898-2906
  • Peer Reviewed
• [Journal Article] Identification of IL-18 and Th17 Cells in Salivary Glands of Patients with Sjogren's Syndrome, and Amplification of IL-17-Mediated Secretion of Inflammatory Cvtokines from Salivary Gland Cells by IL-18 (2008)
  • Author(s): Sakai A, Sugawara Y, Kuroishi T, Sasano T, Sugawara S
  • Journal Title: J Immunol 181 Pages: 2898-2906
  • Peer Reviewed
• [Presentation] Function of IL-18 and Th17 in salivary gland of the patient with Sjogren 's syndrome 10th International Synposium on Sjogren's Syndrome (2009)
  • Author(s): Azusa Sakai, Yumiko Sugawara, Toshinobu Kuroishi, Takashi Sasano, Shunji Sugawara
  • Place of Presentation: France (Brest)
  • Year and Date: 2009-10-02
• [Presentation] Function of IL-18 and Th17 in salivary gland of the patient with Sjogren's syndrome (2009)
  • Author(s): Azusa Sakai, Yumiko Sugawara, Toshinobu Kuroishi, Takashi Sasano, Shunji Sugawara
  • Organizer: 10th International Synposium on Sjogren's Syndrome
  • Place of Presentation: Brest, France
  • Year and Date: 2009-10-02
• [Presentation] シェーグレン症候群の唾液腺におけるIL-18とTh17の関与 (2008)
  • Author(s): 酒井梓、菅原由美子、黒石智誠、笹野高嗣、菅原俊二
  • Organizer: 第18回日本口腔粘膜学会
  • Place of Presentation: 東京
  • Year and Date: 2008-09-20
• [Presentation] シェーグレン症候群の唾液腺における病態発現にはIL-18とTh17が関与する (2008)
  • Author(s): 酒井梓、菅原由美子、黒石智誠、笹野高嗣、菅原俊二
  • Organizer: 第62回日本口腔科学会
  • Place of Presentation: 福岡
  • Year and Date: 2008-04-18